Babies nails are very thin. As we grew up and get older our nails become progressively thicker.
Is it not possible that thinner nails are just a sign of winding back the biological clock?
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Thinning nails are one of the first things I noted after a few months of rapamycin use.
Is this common?
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āIs it not possible that thinner nails are just a sign of winding back the biological clock?ā
One would hope so 
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Especially the thinning of my toenails that were becoming disgusting (imo)! Now after 6 months they are much nicer. As body parts go I really donāt like feet in general though and the condition of toenails I see in the hospital is appalling.
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The rate of growth of nails is one thing that reduces with biological age.
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Yes, with slowing their growth nails thicken, because the nail cells (onychocytes) sort of pile up. Now the question is, does rapamycin make nails grow faster again or reduces onychocytes growth?
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Peter Attia has mentioned that what he has noticed is much slower growing nails when he is on rapamycin.
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Google is always risky with medical conditions, but it helped me with a strange rash on the inside calves of both legs. That was listed as a possible side effect of a medicine I was taking at the time. I stopped taking the medicine and the rash went away.
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Looking good. Iām 62 male, hair has been turning white for last 20 years. Iāve read that some people report their hair becoming darker on Rapa but Iāve noticed no difference in fullness or color after 6 months. Curious, has your hair naturally darkened with Rapa or did you add some color?
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Yes, my hair has started coming in black in my beard and scalp. Solid blackā¦I am naturally brown blonde with tints of red.
A hair tonic I ceeated with oderless DMSO, ECGC (green tea capsules) and Reveratrol (capsules) has created a natural match to my youthful hair. With my current natural hairā¦I have no grey hair. Very natural.
My pubic hair and arm pit hair is not grey eitherā¦ no tonicā¦lolā¦it had been grey a few years ago. So I think rapamycin is doing something to hair colorā¦ much of my scalp hair is brown again too. Using rapamycin 3 years come August. Hope that helps.
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Recently I was diagnosed with lymphedema. Out of curiosity I searched sirolimus/lymphedema and was startled to find case studies and papers linking the two. I started Rapa in Nov '21 and the lymphedema started in July '22. I never gave it a second thought that they could be related, but according to some papers Iāve read it can start as much as 6 months after dosing is started. Granted, the doses the people were on were for cancer treatment or transplants, but it got me thinking and concerned. I have seen significant and wonderful changes in taking Rapa at 5 mg once/week, but am wondering if it has contributed to my lymphedema. I have no family history of it and other causes such as local trauma, immune diseases, etc. have been ruled out. Wanted to find out if anyone else has seen anything similar?
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Are you still taking Rapa?
Took my weekly dose on Monday (before I actually researched this possible connection). I am getting lymphatic drainage done with compression therapy starting in July. I am going to go off Rapa to see if there are any changes. Iām having a hard time accepting that the Rapa is causing it as according to my research itās rare (and are only documented in much higher doses) and there are studies going on right now advocating the use of Rapa for lymphedema. Iām getting big time cognitive dissonance over this.
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had the same issue after a couple months or so of rapamycin use. Stopped rapa after a few more months. Started taking lysine for mouth sores and it also seemed to help the lymphedema in lower legs, ankles, feet.
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were u still able to do rapa without having to do Empagliflozin any more ? and no more lymphedema ?
I have stayed on empag and rapamycin, leg edema improved still to this day
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What is your empaglifozin dose?
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I am taking 1/2 of a 25mg, i think kidney function has also improved, my GFR has gone up
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I found out that the bubbly feeling is not afib. It seems to be tied to the ubiquinol COQ10 supplement I was taking. My wife had the same feeling. We both stopped it and the feeling has not returned. Doesnāt seem tied to Rapa as my wife is not taking Rapa.
Glad itās not afib.
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I would normally suspect cardiac issues, but I wore a holter monitor during the time of the edema (due to other issues I had going on) and they found nothing out of the ordinary. I have also had multiple blood tests and have ruled out immune disfunction, glucose issues and other things that may have been obvious. I am on canaglifozin and have been dosing acarbose at 100 mg per meal. I am very fit, do strength training 4 times per week, watch my diet (for the most part) and otherwise feel fine.
As a side note I wrote a note to Matt Kaeberlein and asked him if lymphedema was possible with rapamycin. Here was his response:
Iād think about probability not possibility. Itās possible youāll develop stomach bleeding from aspirin and die, but not probable. IMO, itās improbable that low dose weekly rapamycin would cause unilateral lymphedema but certainly itās possible. Very infrequent if so.
I have been doing more research and found that there are also cases were Sirolimus is being used to treat lymphedema with some success. Iām very confused right now and have decided to go off Rapa for a couple of months to see if this resolves.
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