Got my first ever herpes labialis / canker sore

Got my first ever herpes labialis this week Wednesday’s so 6 days after my third dose (4mg), anyone experience something similar? I took another 6 mg last Thursday too because I didn’t realise I was in the prodromal phase of herpes

I think they are actually aphthous ulcers/canker sore, not herpes labialis.

At least that (the canker sore) is what is the most common side effect of rapamycin. I got one once after a few months of use when I was going from something like 3mg to 4mg/week, it went away after 3 or 4 days and I’ve never had another despite going as high as 26mg a week at one point.

Details:

Definitely not a canker sore as it was outside of my mouth partially dtratified squamous epithelium (ie my chin under my lip)

Interesting and surprising. I don’t think I’ve not heard of this type of sore you mention with regard to rapamycin use. Have you ever had a herpes labialis sore before?

I found this when I searched on “labialis sore” and rapamycin: It seems rapamycin is used as a treatment for these sores sometimes:

We had a bit of a conversation about similar issues in this past post:

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Never before that’s why I took another dose as I didn’t recognise the prodromal symptoms (burning sensation, small papules)

We have had reports of different skin rashes or possibly infections. Here is another instance (and discussion below it), in a post as part of the “side effects” thread: Side Effects of Rapamycin (part 2) - #3 by aaa21usa

Interestingly some suggested it could have been herpes too but @aaa21usa said he never had herpes before, like me but what I had sure was herpes

Is there anything else going on in your life that might be tied to the outbreak of herpes labialis… increased stress, new relationship, etc?

A canker sore is an apthous ulcer not a herpes sore (HSV!). They look different (check out pictures online).While Rapamycin does commonly. cause apthous ulcers, I have not seen anything about HSV1, which is a virus present in about 50% of the adult population. As admin says canker sores are annoying but small price to pay for the benefits.It sounds like you increased the dose dramatically just before the outbreak. There is a theory – as yet unproven – that increasing the dose too rapidly inhibits not only mTorC 1, but also mTor C2, which causes the outbreak. The whole idea behind intermittent dosing is to inhibit mTorC1 but NOT mTorC2, as I understand it. Informal consensus is Kanka liquid really helps with these sores. I had to go off Rapamycin for a couple of weeks until the sore went away and then lowered the dose. Have never had a recurrence.

@Arhu is an MD, so I’m sure he’s familiar with all these conditions.

I’m just surprised that he had an outbreak of a herpes sore with no previous experience. I guess it could be dormant and for whatever was reason - stress, etc. or perhaps rapamycin (though I’ve not heard of this before and can find nothing in the literature) that stimulated the outbreak.

If it is indeed herpes simplex, it’s probably not related to rapamycin, unless taking two doses causes stress or some other factor. Herpes lies dormant for years in many people and then presents at times of low resistance.As you said there is nothing in the literature that I could find about rapamycin causing herpes sores but plenty about apthous ulcers, which are fairly common. Lycine supplementation is supposed to help with herpes outbreaks. There is a blood test for HSV1 and HSV2.

this definitely was herpes not a canker sore

two and a half weeks prior I had a small cycling accident with some road rash including on my face and a tetanus booster but by the time I got the outbreak the road rash on my face had healed completely already

I’m not an HSV1 expert but there are many possible triggers for an outbreak including getting too much sun. Do you think it was somehow related to rapamycin?