8mg of rapa each week and on low dose Reta… no issues at all
.5 crp and low A1c (even without the drugs).
I have hashimotos that is no worse or better since starting.
When I turned approx 50, I could no longer handle gluten… after I started rapa, related or not, my sensitivity disappeared
All this is to say, based on my N=1, I would not worry in the least about being a 60yo woman and taking these things together. They might negatively affect you, but I don’t personally believe being a woman is related. Take anything I say with a grain of salt!
Btw, I used to take metformin for my high glucose spikes, but it didn’t control them very well. Since being here, I’ve switched to dapagliflozin and Acarbose which help me significantly more… because my A1c was already good, there has not been much of an effect there.
• Metformin → AMPK activation and improved insulin sensitivity
In theory you’re covering three major metabolic/aging pathways at once. The main thing to watch is appetite suppression and making sure calories and protein stay high enough to avoid muscle loss.
Obviously still very experimental since there are no clinical trials on this stack, but from a pathway perspective the combination is interesting.
Curious if anyone else here has run the same stack and what their experience has been.
I’m taking 1 mg Reta on Monday evenings and 6 mg Rapa Friday evenings. 65F. Tested giving up the Rapa and oof joints hurt, have osteoarthritis in my hands that I’m hoping will improve. No weight issues. Hoping the Reta helps lower my A1C from 5,6 (despite low carb for years and hypoglycaemia if I work out late afternoon) and slow progression of the OA.
48 year old male here. 2mg Reta microdosed weekly, 6mg weekly of Rapa, and 500mg (twice daily) XR Metformin. Last A1C was 4.2. No issues on that stack at all. I hope that helps.
Not for me, unfortunately. After being on it for a year and a half, my resting heart rate is still much higher than previously.
What I think is happening based on what I’ve read is that people who are lean and using it have a higher increase than people who are overweight and lose a lot of weight with it
Have you tried other GLP-1s? I have similar issue with Tirzapetide, and my RHR is ~10 beats higher/min, after a year and a LOT of cardio. I would be 45-55 resting based in the past, and now 60-65. Also not taking high doses - 2.5mg / week of Tirz.
Some of this may be inverse relationship between lowering blood pressure, and heart rate. Heart works a bit harder to circulate blood is my simple understanding.
I know lower BP = good. What is the impact of a increased RHR longer term?
I’m on semaglutide (oral tablets @ 14mg/day), rapamycin and imeglimin (and acarbose with carb meals), and all seems to be going well. I need to do blood testing soon to validate, next week. Imeglimin. A new and novel drug thats better than Metformin
70 y/o male here. My longevity clinic in Scottsdale has me on 1x week Tirzepatide and 5x per week of Tesamorelin (for my visceral fat)and Glow as well as 6 mg weekly of Rapamycin on a three month on/off schedule, acarbose daily with food as well as Prolon at a minimum quarterly and monthly, if necessary.
I follow their protocol and they tell me my numbers are improving. I’m not nearly as educated as y’all on this site regarding the scientific aspects of my peptides, rapamycin, acarbose, etc. All I know is it working.
You can get it from Chinese grey marker vendors. The best introduction of how to navigate this space is here https://stairwaytogray.com/. This will give you an idea of what you’re getting yourself into.
If you decide to proceed, be sure to join their group where they give access to some vendors. Link is at the bottom of the page.
