Retatrutide, Rapamyacin & Metformin - anyone combining? Any issues or synergies?

#1

I’ve started Retatrutide, going ‘low and slow’ in the hopes of reducing my visceral belly fat. Meanwhile I stopped my low dose Rapamyacin / Metformin. I was getting mouth sores every couple of months which was annoying and I didn’t want to jinx the Retatrutide. However I’m a female ~60 yr. and females are know for their autoimmune issues as we age. I want to keep any current or future inflammation issues in check.

Has anyone tried combining the two? Retatrutide & Rapamyacin? Or the three? Retatrutide & Rapamyacin & Metformin?

#2

Good news, you can ditch metformin since you’re taking a GLP1 agonist.

Since rapamycin elevates my blood glucose, pairing it with retatrutide has worked out well for me, and I don’t have to worry about elevated glucose or borerline high A1c anymore. No side effects from this combination in my case.

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