- What’s your schedule for rapamycin during flu season in general? Do you pause Rapa, if you’re on risk for an infection?
- After an infection, how long do you wait until your next dose? Do you measure anything beforehand (e.g. HRV)?
Many thanks 
I have rarely gotten sick over the past 3.5+ years I’ve been on rapamycin (perhaps 1 small cold in the entire period), so I really don’t alter my schedule at all based on season. And, given the (admittedly small sample size) results in the Kaeberlein rapamycin survey paper Evaluation of Off-label Rapamycin use to Promote Healthspan in 333 Adults (New Paper).
The 37 respondents who took rapamycin continuously before, during, and after SARS-CoV-2 infection had the lowest rate of moderate or severe infections among all groups. Only 5 individuals (13.5%) reported a moderate infection while the rest (88.5%) reported a mild case. There were no reports of hospitalization or long-COVID among this group.
Among the 17 individuals who took rapamycin prior to but not during their SARS-CoV-2 infection, 10 (58.8%) reported mild symptoms, 6 (35.3%) reported moderate symptoms, and 1 reported a (5.9%) severe case (trip to hospital). Only one of these individuals did not resume rapamycin use after SARS-CoV-2 infection. There were no reports of long-COVID among this group.
So - I’m thinking right now that I’d not stop and just keep taking my rapamycin. Perhaps lower the dose a little to say 6mg/week vs. my typical 8mg to 10mg/ week dosing schedule.
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