I just found this which answers much of my question. I guess my key question is how quickly does epigenetic age and other biomarkers creep back up after stopping a cycle? My hope is to cycle off for long periods, perhaps allowing a higher dose when on cycle
"In Peter Attia’s podcast interview with Joan Mannick and Nir Barzelai 83 he mentioned his dosing protocol and the rationale behind it:
Joan’s paper 83 suggested 5 mg once a week was a pretty good place to start
Peter triangulated that data with data from Matt Kaeberlein’s dogs 27
He settled on 6 mg once a week
What still remains unclear for Peter is how to cycle it
Current protocol is—on for 8 weeks, off for 5 weeks
“But, truthfully, without more advanced testing, I’m really making it up and therefore I don’t like talking about it like I just did .”
The short answer is we don’t know much about the longevity effect in humans, as there have been few clinical studies.
Peter Attia is no longer cycling off I believe, as most people have gone off that protocol because most people are having few side effects. But - you can do whatever you want obviously.
The issue with Rapamycin is that it has positive and negative effects. The question therefore is the balance between the positive period and negative period which is a complex question.
I have my own theory of aging which concludes that Rapamycin in increasing autophagy is useful, but because of its negative effects weekly or even fortnightly (given the half life) is too frequent.
This would be difficult to measure in a human being because there are many other factors. For example i am running an intervention with a large number of components and although i try to isolate out the effects of each one it is not that easy or reliable i can only measure the overall effects.