Rapamycin & Marijuana/Kratom

Hey Everyone!

I was wondering if anyone takes rapamycin that smokes Marijuana or is taking kratom or similar opiates? I am wondering if there are any drug interactions I should be aware of? I don’t smoke but my wife does and before getting her on Rapamycin I want to know if it would be ok!


We have a thread here you should read. Kratom is pretty new so we haven’t run into it here yet or discussed it, but I recommend you research it and post anything you find here for other people.

Read this thread and the links it provides: Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs - #4 by RapAdmin

And I recommend you get up to speed on all the dosing and potential side effects so you are pre-aware: Rapamycin Frequently Asked Questions (FAQ)

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And marijuana seems like it might age people faster:


These findings suggest cumulative and recent marijuana use are associated with age-related epigenetic changes that are related to lifespan. These observed associations may be modified by alcohol consumption. Given the increase in use and legalization, these findings provide novel insight on the effect of marijuana use on the aging process as captured through blood DNA methylation.


All the “marijuana use” research is contaminated by the huge prevalence of recreational users (already a huge risk group in itself) + most people smoking it and not taking it via edible/oral routes. Ppl who take it to get high/psychoactive effects are not the same who take cannabinoids at sub-psychoactive doses for relaxation/anti-inflammation.


I found this page helpful for checking interactions


For marijuana this is what comes up so I’d be cautious “marijuana will increase the level or effect of sirolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.”


Hope nobody is using Kratom. Just say no!


Kratom is an immunostimulant and shown to help with covid but other than that i don’t think they interact

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Yeah Kratom is a legal Supplement where I live and I’ve read some really good things about it, especially like you said about helping with Covid etc

Very interesting, although assumes daily Rapa doses for organ transplants.

Also, only indicates whether increase / decrease vs Rapa, so not sure how useful: If say > or < 10%, probably not a factor.

But number of items impacted via other routes than CYP3A4, such as:

lovastatin will increase the level or effect of sirolimus by P-glycoprotein (MDR1) efflux transporter.


Or even this, re Maitake:
sirolimus increases and maitake decreases immunosuppressive effects; risk of infection. Effect of interaction is not clear, use caution.