I’ve always wondered about the recommendation to take the weekly rapamycin dosage all in one day. What is the rational for this? Why not take it throughout the week (e.g., daily) to maintain on constant dosage rather than a big spike that diminishes throughout the week? I seem to recall that Matt Keberlein did an experiment which showed he was nearly at the zero level in his blood after 7 days. Sorry if this has been discussed before.
Best Regards.
@John_Hemming has a theory that the trough is as important as the peak.
Other than that, I don’t think we have much data on daily vs weekly.
I am also running on about every 6 weeks or slightly more. I wait for 6 weeks and then decide on a good time to go for it.
I believe the general thinking on this is you want to try to mimic the mTORC1 cycles of youth (sometimes on, sometimes off) not just block mTORC1 all the time. This is from Brian Kennedy in his discussions on rapamycin.
Also - you want to avoid mTORC2 inhibition - so taking breaks helps guarantee that.
You can see past discussions here:
Thanks for all of the great discussion links. I am contemplating a couple different strategies.
Best
My personal experience of taking it every other day for a few months was that it seemed to cause me too much immune suppression. I didn’t change my total amount but simply took lower doses more frequently. I was working in a hospital at the time though so in hindsight it probably wasn’t the best idea for me personally.
People can believe in pulse dosing or they can be wrong 
Well the idea of daily was not really a serious one until this recent study.
Now it’s a legitimate debate. I still do 5mg weekly for now but waiting for more data.
I’d be interested in trying daily. I generally find rapamycin makes me feel good on the day of taking it.