I have tried to use 6mg a week for antiaging, my menstrual cycle is normally very punctual every 33 days, my sex hormones and fertility hormones are very good, even AMH over 4 ng/mL, … which is very high for my 37 yrs.
So suddenly even first month after taking rapa i got delayed menstruation, stopped it and tried again it again happened.
I kinda freaked out and stopped the experiment.
I was reading some trials and if i remember well this could be a sign of it working, so drastically slowing my ovaries? but sitll i am afraid to use it like this
last time i got menstruation earlier, but this is after already stopping rapa for 2 months.
Bryan Johnson’s decision also got me thinking.
I guess i Have to do some reading
on a side note: has anyone tried omipalisib?
Have you reviewed the relevant threads from this story? Rapamycin for Fertility and Menopause; Clinical Results
@medaura took 5mg for almost a year prior to pregnancy, did you see any changes similar to what @Forever29 has seen?
Also - other threads:
yes i read a lot on it and concluded it’s safe to take 6mg, i dont know if it matters but my hormonal levels are more in line with late 20s, and I look unusually young. but still freaking out over aging so want to slow it down
What is your weight? You may want to start at a lower dose (e.g. 3mg) and see how it goes for a while, then slowly increase.
i trialed lower dose too , dont think that was an issue actually unless i need 1 mg, and why would 6mg and later 5mg stop my cycle? wish to understand the mechanism before taking it again
Can I read anywhere more on what Bryan Johnson shared that rapamycin could cause an increase/acceleration of aging in humans across 16 epigenetic clocks?!
I will make my usual point of considering a lower frequency.
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See these threads for why Johnson is wrong on this:
I recommend you listen to this podcast where they talk about epigenetic clocks and current use. In short, epigenetic -related aging is thought to be one small but undetermined part of aging, and the clocks today really are not valid for any decision making by consumers.
Hi !
I am 37 too and the same thing happened to me. According to Chat GPT this is quite normal, it means it worked well 
Could we chat together in private messages ?
hey sorry i just saw this, sure message me, i am curious what ur experience is. Unfortunately i have a bad news, so when i noticed this it happened right after taking it, my AMH was consistently 29 AMH pmol/L, last time checked 10 months ago when my cycle was disturbed after rapa, i tried rapa few more times and it shortened my cycle or something else did. but i had consistently 33 days for 10+ years, I now measured AMH it fell to 16, so sharp fall in just 10 months, sounds like rapid aging.
Unfortunately, I have bad news, so when i noticed this it happened right after taking it, my AMH was consistently 29 AMH pmol/L, last time checked 10 months ago when my cycle was disturbed after rapa, i tried rapa few more times and it shortened my cycle or something else did. but i had consistently 33 days for 10+ years, I now measured AMH it fell to 16, so sharp fall in just 10 months, sounds like rapid aging
For those who dont know AMH is the quite reliable assessment of ovarian age.
I am now so afraid to take it considering some data and well my experience.
check my update, following rapa, my AMH very sharply fell
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