You are cordially invited to a webinar hosted by AgelessRx on our upcoming paper presenting the results of bioavailability data of rapamycin comparing commercially available generic with compounded tablets.
background on the study (why we needed to do this study)
results of the study
the practical implications of the study
a mini-review of rapamycin in the lens of sirolimus levels
The webinar will be recorded and available on the AgelessRx YouTube channel shortly after for those who can’t make it.
Bring your questions and your thinking caps!
If you have any questions you would like answered, please post them here and we will queue them up and do our best to make sure we have time to address them!
Best
Girish Harinath
Senior Research Manager
Applied Science, AgelessRx
Should we try to strive for some kind of standardized way of sharing dose regime because bioavailability differs between generic and compounded Rapamycin? For example “generic 6mg/weekly”. This to avoid confusion.
What is the next step after this? Will you do deeper work around this in the clinic?
Curious to know what is the latest status of the PEARL trial? When will that data be published?
I recently purchased a bunch of Glenmark Everolimus thinking that it might be much more package efficient (given the 10mg tablets), but the packaging on these is quite large, taking must as much space as probably 10X1mg rapamycin tablets.
Here is a link to the webinar on Youtube where Sajad Zalzala, Girish Harinath and Stefanie Morgan from AgelessRx go through the Rapamycin bioavailability study.
A question that is controversial and perhaps a bit off topic but on everyone’s mind…
Is Rapa AUC or peak more important for longevity and immune function impact of Rapa? IE, should a person aim for a high peak (bbb?) but a short residence time (clear quickly) to reduce side effects…via taking a higher dose of Rapa on empty stomach, for example?
Or should a person aim for slow absorption and long residence time even at the cost of lower peak rapa in blood, possibly by taking a lower dose of rapa (perhaps two doses in short sequence) with a fatty meal?
Speaker 2 12:24
Okay, do you have any sense on longevity purposes, whether it’s AUC?, CMax?, what do you think are key factors in in the effectiveness of rapamycin?
Speaker 1 12:36
So, you know, you you raise this point, I’ll have to come back to the mouse, because we don’t know. My general feeling is it’s probably something like the AUC and this is based on the fact that, you know, despite what some people might say, the chronic rapamycin treatment has still been the most consistent effect. And the one test that really go did it same time. Test different ways to do it, by the ITP every day in the diet, still did the best.
Yes, I saw that before; good interview. I’m still gathering data (opinions) before I adjust my methods. It’s nice to get multiple points of view. I already know that there isn’t a clear answer, but I’ll go with the dominant leaning among the smartest people once I know what that is.
Yes that would be good for those people that can take blood tests. However, the answer to that question would not be simple and would differ depending on the frequency of dosing.
I’m not sure where you would get the pure powder form from. However, I would assume it would have the same bioavailability as the compounded versions since the compounding pharmacies use a powder form when mixing up their capsules or tablets
To my knowledge, compounding pharmacies measure out the rapamycin powder, add an excipient/filler/binder, and make up the capsule or tablets that way.
The paper here indicate that compounded Rap is not as bio-available, not sure why that would be. Unless the actual amount indicated of the active ingredient is not in the pill/cap? and that paper only shows the blood level from the compounded version but not the generic version so one cannot tell from that paper what is actually happening.
I get >99% Rap for about $0.50 a mg. Dosing 6mg of powder is not a problem for me but for most people, it would be.
The commercially available tablets use some form of encapsulation or absorption enhancement materials to improve the absorption. Since ingesting the compounded form, which would be the same as the raw powder form from a practical perspective, does not have the encapsulation, therefore there’s lower absorption and bioavailability.
AgelessRx had worked with a compounding pharmacy partner to include ingredients to enhance absorption. But then we realize the cost of doing so made it far more expensive than it’s worth (It doubled or tripled the cost of the compounded capsule, whereby tripling the amount of rapamycin in a capsule only increases the cost marginally or a 15mg capsule is only slightly more expensive than 5 mg capsule)
