Agreed, and not only that but in men the main hormone is testosterone while in woman it’s estrogen. Estrogen is found plenty in plant foods, yet testosterone inducing compounds are mainly found in meat. Obviously, non-scientific but practical way of looking at it.
1 Like
Statin use moderates APOE’s and CRP’s associations with dementia and is associated with lesser dementia severity in ε4 carriers
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13543
3 Likes
@A_User I support your crusade against LDL and APOE.
You are the most prolifigate at finding articles and studies supporting statin use.
Thank you.
3 Likes
I’m also a fan of statins, but in very low doses. I’m going to try a very low dose myself (even though my blood markers are all normal).
2 Likes
Just took my first dose of bempedoic acid tonight. Here’s hoping for no side effects tomorrow.
As an aside, my latest shipment of bempedoic acid costs 7 USD a month from India. In the US, it costs 395 USD.
4 Likes
Doesn’t Bempedoic acid have similar side effects as statins (joint and muscle pain, stomach pain, etc)?
1 Like
I have been taking BA from de USA. Really this price that you achieved is tempting, but i’m hesitant about quality this meds from India, as i didnt find a reliable brand.
B
Blockquote
Bempedoic acid has statin like properties without the side effects. Supposedly. I will find out.
The brand of Bempedoic acid I am using is called Brillo. I’ll measure my cholesterol at my next blood work and I’ll know if it’s the real deal or not. For this price, I’ll take the chance.
It’s made by Sun Pharma which is the largest pharma company in India. That makes me feel safer.
Waking up this morning after my dose last night, I have no muscle soreness.
@LaraPo I was reading somewhere that said you can use bempedoic acid and a statin together. I didn’t get too far into that research as statins are a no go for me. But it may be something you can consider like what @Paiva (below) is doing.
2 Likes
I have taking BA, Rosuvastatin and ezetimibe since 2y ago. Nothing to report except a mild pain in the legs sometimes.
2 Likes
As i have taking rosuvastatin and ezetimibe for long time then, when i start Rapa 3 years ago, my lipids rose. But decresing again w/ BA add. For now, ApoB, LDL and TG it are around 60-70mg/dc. But i increased ( a month ago) Rosuvastatub a little bit, as i’m intend put it around 50-60mg/dc, mostly ApoB.
4 Likes
Bempedoic acid supposedly is limited to decreasing cholesterol synthesis only in the liver and has essentially no effect in extrahepatic tissues, so muscle soreness should not be a thing. Seriously considering ordering from overseas and adding to my ezetimibe/PCSK9i regimen.
3 Likes
Do you have any sense of how very low dosing of bemp might further lower Apo B if already taking PCSK9i (with or without ezetimibe)?
Numerically, no I don’t, only that I want to get my ApoB down as low as possible with as few side effects as possible. PCSK9i + bempedoic acid + ezetimibe appears to be an ideal combination. My insurance won’t pay for BA since I’m already on the other two and my LDL is already “low enough” from their perspective.
3 Likes
Seems Citrulline may help reduce LDL, TC, cytokines and inflammation.
Citrulline group had a notable reduction in FBS (p = 0.04), total cholesterol (TC) (p = 0.02), low density lipoprotein (LDL-C) (p <0.001) and high-sensitivity CRP (hs-CRP) (p <0.001). Also, a significant increase in lactate dehydrogenase (LDH) concentration (p <0.001) was observed in the intervention group at the end of the trial.
1 Like
I am adding 2 mg rapamycin a week to start with as I am never going to start otherwise.
Currently taking 5 mg rosuvastatin a day and 2 mg rapamycin once a week.
1 Like
I have decided to try additional Citrulline. Whether I will see any difference is hard to say. My biomarkers vary so much anyway that it may not be able to see an effect even if there is one.
1 Like
I think your second paragraph cancels/contradicts the first one. Basically, you are saying you want to start 2mg RAPA a week, as you are never going to start otherwise and then on your last paragraph you say currently you are taking 2mg per week? Out of curiosity which one is it? Real question btw not trolling (since it seems you do a lot of research)
@LaraPo I think you have been doing RAPA (for other reasons than longevity) for a long time. Can you please give an overview of how long and dosage and if you were doing daily or weekly etc… and did you ever feel it is negatively impacting your health in anyway? Plus knowing now what you know about RAPA do you feel its helped you in your health (apart from the initial reason for taking it) and do you feel you’re better off (health wise) than you similar age friends who may not be taking it?
Reason for my question has to with the fact that I’m trying to come up with the best possible dosing and frequency. Lately, I tend to think I might seem better (health wise) if I take say 2mg twice per week. Thanks,
ps sorry if you have already explained such information before, I searched but couldn’t find.
2 Likes
I’ve been doing it for almost 14 years. Rapamycin is an amazing drug, it keeps me alive and fully functioning. I came to a conclusion (for my situation) that taking it with breaks works better (measured by markers and overall well being) than taking the same dose (1 mg) every day. That dose, if taken every day for a long time, apparently accumulates and suppresses immune system too much (mouth sores, skin problems, acne, high BP, high glucose, high lipids, loss of weight, feeling cold all the time, less energy, bacterial infections, etc). To get back to normal, I tried to reduce the dose and introduce breaks from time to time. It completely changed everything - my biomarkers improved, gained some weight, have more energy to exercise daily, no bacterial infections or skin problems, glucose and lipids normalized. I’m currently on 2-3 mg per week followed by a week break. Sometimes I take a two week break when I feel that the drug again accumulated in my system.
I cannot tell if it helped my health apart from the initial reason. Before I lost kidney function I was absolutely healthy and active (scuba diving, downhill skiing, hiking, etc). All my wellbeing at present is dictated by the health of my transplant. I take rapamycin for keeping my transplant healthy and as long as possible. Rapamycin positively affected my ruined health: it supports my transplant. But besides that primary function, I also enjoy its benevolent side effects 
, like overall rejuvenation and slowing the aging process. And it does show in appearance, skin, flexibility, posture, muscles tone, etc. I do look years younger than my friends of the same age. Most likely because of rapamycin.
If you want to take rapamycin for a long time, it’s better imo to take a smaller dose (something like 2 mg/week), especially being young as you are.
11 Likes