Potentially amazing new molecule - SLU-PP-332 (exercise mimetic)

#101

I don’t know of any peptides other than ARA 290 that can repair nerve damage and address neuropathy.

I don’t have any back issues, I can touch my toes and I bend over to pick crap up out on our commercial property every morning. No issues with any of that. I hauled a heavy load of garbage out of the woods yesterday up from the river bank that I had to scramble down to get to. No issues. I manage 23 acres of park like wooded property. I clean up homeless encampments on a weekly basis.

I do think that all the anti-inflammatory benefits of the various peps are helping but that only goes so far. Nerve pain is it’s own unique thing.

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#102

A high quality analytical balance or mg scale to weigh it out, then dissolve in a small amount of very pure DMSO and dilute with a larger amount of PEG400.

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#103

One of the more accurate ways to do that is put it in water. No it won’t dissolve on its own but it will make it easier to accurately dose. It will disperse nicely when you shake it and it looks “homogeneous” when you do that.

I tried a lot of things to dissolve it. I have a 30k RPM high shear mixer and that did not help. I tried it in my ultrasound mixer but no joy there either, although it probably didn’t have enough power (1,500 watt) for this application. Tried DMSO, which will dissolve it but when you put that mixture in water it didn’t “blend” for me. It was like a cloudy swirl in the water and never looked “right” to me.

So I put 50mg of SLU powder in 25mL of distilled water. Then 0.25ml = 500mcg dose.

Shake before using, that will provide a fairly accurate dose.

Since many are selling SLU capsules and pills (250mcg doses), with no effort to make it more bio-available/water soluble, dissolving it in water should achieve the same “potency” as taking a powder, cap or pill.

This is one of the easier ways to get a reasonably accurate dose, with a non-soluble powder.

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#104

As discussed further up this thread, the human dose of SLU-PP-332, if based on the mouse results, would be extremely high.

Since there have not been any human clinical studies that demonstrate effective clinical dosing, I’m still not sure that such a low dose, as is being promoted by the bro-science guys, is going to be truly effective. They have no clinical evidence to back up their claims. As in Zero evidence but lots of anecdotal.

Anecdotal can be helpful, as we have had some reports of improvements in various functions but that’s not what I’d call definitive.

In mice the dose was high, up to 50 mg/kg twice per day and as “low” as 25 mg/kg twice per day PLUS it was administered as an intraperitoneal injection (not orally) to get the results in the mouse trials.

To convert that mouse dose to a human dose multiply by 0.081 = 4 mg per kg.

I weigh 64kg x 4mg = 265 mg injected daily for 28 days to duplicate the mouse dose and duration in the study. High dose and a significantly more effective deliver method than orally.

So I really do not understand how taking 1/1000 of the dose orally (vs injected) would have the same effect on humans.

256mg / 1000 = 0.256mg = 256mcg

While many are reporting benefits at this dose, there is no control, there is no testing and no structure to this process but there is a huge profit potential at that low dose.

Having said that, I think I’m going to try some high dose oral testing on my fav guinea pig.

Even the developers recognize that injection is currently superior to oral and they are working on a new version to make it more effective as an oral product vs injection.

The next step in developing SLU-PP-332 into a drug candidate will be to refine its structure, ideally making it available as a pill instead of an injection. Then the drug would be tested for side effects in more animal models before making the jump to human trials.

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#105

Keep us posted on your dosing regimen in terms of efficacy!

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#106

There’s a guy on Reddit who boasts of taking 80 mg per day, “with zero sides and all the benefits,” which include improvements in sleep, cognition, libido, and muscle mass. I’m glad he can afford the cost, but he could end up like one of those dead body builders.

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#107

I’m going to try a month (July) of 50mg per day (1,500mg) out of curiosity LoL!

But I have to do my FOX04-DRI cycle next week.

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#108

Go ahead, man. It’s one of the perks of the job–getting high on your own supply.

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#109

LoL!! so true, it’s a slippery sluup :slight_smile:

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#110

I’m not sure if it works yet. But if it works only at ultra-high dosages, I’ll give it a pass. Same with SS-31, another substance said to be transformative at 50 mg or higher for several weeks or longer. I’m happy with the pain relief and tissue repair I get from some of the most popular peptides.

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#111

Is anyone concerned about cancer risk with this?
I can see how addressing mitochondrial dysfunction would be protective regarding some types of cancer but there appears to be a link between errα overexpression and risk/progression of certain cancers.

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#112

What’s your operational definition of “sexual performance?” Is that stamina? Libido? Erectile function? Something else? I know that sounds cute, but if we’re too embarrassed to ask these questions and clarify the meaning, these anecdotal reports are of limited value.

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#113

While I’m tempted to try this, I must remind myself that it’s way, way riskier than the other off-label compounds I’ve tried or am considering trying. Although there are anecdotal reports of its results with few side effects, there seems to be no long-term data. With rapa and SGLT2 inhibitors, we have full FDA approval and a long post-market period. I take both of these, and I think they are pretty safe, especially considering I’m healthier and am taking lower doses than the subjects in the trials. Even Retatrutide, which I’m considering taking, has passed Phase 2 trials. This compound has zero human data. It achieves something you can get with exercise. Yet it seems we are discussing it as it has the same risk profile as well well-studied drug, if only we could get the dose right . . . Am I missing something here?

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#114

Stamina - multiple male orgasms in 1 session
Erectile function - goes with the above
Night time penile tumescence (NPT) - more than “normal”

Those 3 were mentioned, keep in mind this is a very basic evaluation, not run by someone who knows what they are doing :slight_smile:

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#115

As Reta is a fairly “new” peptide in the GLP!-RA group, there is limited long term data, but…

There is human data and is in several Phase 3 trials. Also I know quite a few people using this, including myself, my wife, and a bunch of friends and family.

Retatrutide is currently in Phase 3 clinical trials for the treatment of obesity, type 2 diabetes, and non-alcoholic fatty liver disease. These trials are being conducted by Eli Lilly, with the aim of assessing the drug’s efficacy and safety across larger populations. The Phase 3 trials for obesity are part of the TRIUMPH clinical trial program.

Key aspects of the Phase 3 trials:

  • Focus: The trials are evaluating retatrutide’s impact on weight loss in individuals with obesity and overweight with related comorbidities, and also in those with type 2 diabetes.

  • Mechanism: Retatrutide is a novel triple agonist that activates GIP, GLP-1, and glucagon receptors, potentially leading to greater weight reduction compared to other medications.

  • Timeline: The Phase 3 trial for obesity is expected to conclude in early 2026.

  • Recruitment: Many of the trials are actively recruiting participants.

  • Potential Outcomes: Preliminary results from Phase 2 trials showed significant weight loss, and the Phase 3 trials aim to validate these findings in larger, more diverse populations.

Specific Phase 3 Trials:

  • TRIUMPH 3:

This trial focuses on the efficacy and safety of retatrutide compared to placebo in individuals with severe obesity and established cardiovascular disease.

  • TRANSCEND-T2D-2:

This trial is investigating the efficacy and safety of retatrutide versus semaglutide in adults with type 2 diabetes and inadequate glycemic control.

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#116

What dose / cycle are you doing for foxo4-dri? I recently created a longevity and synolitic protocol with the help of AI and ran a dasatinib / quercetin, followed by foxo4-dri, followed by epitalon with a number of other supporting peptides and supplements. The AI helped me decide when to add or remove certain things based on their biological targets.

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#117

6mg per day for 4 consecutive days, twice per year. Last month was our second time using FOX04-DRI
Prior to that I do a 1 month cycle of Epithalon and MOTS-c

I’ve previously done senolytic cycles with a little dietary supplement formula I developed using Q + F and a bunch of supporting compounds. I did multiple (5) DNA methylation tests over 4 years with good/interesting results. I’ve posted those results previously.

Also did the the same tests with 4 volunteers over a 7 month program and they all had significant improvements in the same tests. I’ve posted those results before.

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#118

I’ve gone through a couple bottles of slu-pp-32

I really like that compound and immediately noticed a boost in energy and HIIT and cycling seemed easier. The body seems to adapt to the energy boost effect very quickly though. I felt it at 300mcg, then 500mcg, 700 before settling on 1.5mg (the pills I take are 750mcg each) as my pre workout dose. I don’t feel that little boost anymore but I do believe it still helps with endurance but it’s modest for me. I like that it feels clean and no come down or anything.

I can’t say I noticed any or much weight loss but I’ve been on Retatrutide and TRT for the past year and that does a lot of the heavy lifting so to speak.

It would be interesting to have someone do a dexa before and after with only slup changing.

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#119

Nice! If you want help developing a standardized questionnaire, I’ve done that before and would be happy to help.

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#120

My comment on “zero human data” was concerning slu-pp-32, not reta. But thanks for summarizing the research! Reta looks pretty safe and very effective, so good risk/reward ratio. If I struggled with being significantly overweight and had limited success with a lifestyle approach, I would definitely jump on it.

As it stands, I’m 17% BF with a reasonable amount of muscle, based on DeXA. I’d like to get to 15%, which I think is achievable but has been difficult because I “fall off the wagon” from time to time.

I’m considering micro-dosing reta, for the following reasons: (1) it should reduce food noise and allow me to achieve 15% BF or perhaps lower without much psychological effort, (2) more generally, it seems to make smart decisions easier to execute, and bad habits less attractive (3) it seems to preferentially reduce liver/visceral fat. I’m not sure I need this because I couldn’t find a DeXA that estimated this in Toronto, but I’m concerned, (4) it seems to be protective of other systems (cardio/neuro/renal), even beyond it’s fat loss effects.

What’s holding me back is that it tends to raise resting heart rate, and mine trends a little high. Despite a VO2 Max of 58 at the age of 66, my resting heart rate is in the low 70s.

I’ve followed @LukeMV 's progress using reta with interest, since we have a similar starting point, although I’m a lot less jacked and older.

Thoughts?

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