Potentially amazing new molecule - SLU-PP-332 (exercise mimetic)

#101

I don’t know of any peptides other than ARA 290 that can repair nerve damage and address neuropathy.

I don’t have any back issues, I can touch my toes and I bend over to pick crap up out on our commercial property every morning. No issues with any of that. I hauled a heavy load of garbage out of the woods yesterday up from the river bank that I had to scramble down to get to. No issues. I manage 23 acres of park like wooded property. I clean up homeless encampments on a weekly basis.

I do think that all the anti-inflammatory benefits of the various peps are helping but that only goes so far. Nerve pain is it’s own unique thing.

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#102

A high quality analytical balance or mg scale to weigh it out, then dissolve in a small amount of very pure DMSO and dilute with a larger amount of PEG400.

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#103

One of the more accurate ways to do that is put it in water. No it won’t dissolve on its own but it will make it easier to accurately dose. It will disperse nicely when you shake it and it looks “homogeneous” when you do that.

I tried a lot of things to dissolve it. I have a 30k RPM high shear mixer and that did not help. I tried it in my ultrasound mixer but no joy there either, although it probably didn’t have enough power (1,500 watt) for this application. Tried DMSO, which will dissolve it but when you put that mixture in water it didn’t “blend” for me. It was like a cloudy swirl in the water and never looked “right” to me.

So I put 50mg of SLU powder in 25mL of distilled water. Then 0.25ml = 500mcg dose.

Shake before using, that will provide a fairly accurate dose.

Since many are selling SLU capsules and pills (250mcg doses), with no effort to make it more bio-available/water soluble, dissolving it in water should achieve the same “potency” as taking a powder, cap or pill.

This is one of the easier ways to get a reasonably accurate dose, with a non-soluble powder.

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#104

As discussed further up this thread, the human dose of SLU-PP-332, if based on the mouse results, would be extremely high.

Since there have not been any human clinical studies that demonstrate effective clinical dosing, I’m still not sure that such a low dose, as is being promoted by the bro-science guys, is going to be truly effective. They have no clinical evidence to back up their claims. As in Zero evidence but lots of anecdotal.

Anecdotal can be helpful, as we have had some reports of improvements in various functions but that’s not what I’d call definitive.

In mice the dose was high, up to 50 mg/kg twice per day and as “low” as 25 mg/kg twice per day PLUS it was administered as an intraperitoneal injection (not orally) to get the results in the mouse trials.

To convert that mouse dose to a human dose multiply by 0.081 = 4 mg per kg.

I weigh 64kg x 4mg = 265 mg injected daily for 28 days to duplicate the mouse dose and duration in the study. High dose and a significantly more effective deliver method than orally.

So I really do not understand how taking 1/1000 of the dose orally (vs injected) would have the same effect on humans.

256mg / 1000 = 0.256mg = 256mcg

While many are reporting benefits at this dose, there is no control, there is no testing and no structure to this process but there is a huge profit potential at that low dose.

Having said that, I think I’m going to try some high dose oral testing on my fav guinea pig.

Even the developers recognize that injection is currently superior to oral and they are working on a new version to make it more effective as an oral product vs injection.

The next step in developing SLU-PP-332 into a drug candidate will be to refine its structure, ideally making it available as a pill instead of an injection. Then the drug would be tested for side effects in more animal models before making the jump to human trials.

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#105

Keep us posted on your dosing regimen in terms of efficacy!

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#106

There’s a guy on Reddit who boasts of taking 80 mg per day, “with zero sides and all the benefits,” which include improvements in sleep, cognition, libido, and muscle mass. I’m glad he can afford the cost, but he could end up like one of those dead body builders.

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#107

I’m going to try a month (July) of 50mg per day (1,500mg) out of curiosity LoL!

But I have to do my FOX04-DRI cycle next week.

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#108

Go ahead, man. It’s one of the perks of the job–getting high on your own supply.

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#109

LoL!! so true, it’s a slippery sluup :slight_smile:

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#110

I’m not sure if it works yet. But if it works only at ultra-high dosages, I’ll give it a pass. Same with SS-31, another substance said to be transformative at 50 mg or higher for several weeks or longer. I’m happy with the pain relief and tissue repair I get from some of the most popular peptides.

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#111

Is anyone concerned about cancer risk with this?
I can see how addressing mitochondrial dysfunction would be protective regarding some types of cancer but there appears to be a link between errα overexpression and risk/progression of certain cancers.

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