Sorry, mis-read your post 
As you have noted there is not a lot of human data on this specific ERRa.
There is a fair bit of interest in ERRa’s though, due to the potential benefits
This is one of the earlier articles I can find on SLU and the link to other studies that reverence this one.
https://pubs.acs.org/doi/10.1021/acschembio.2c00720#
This one may be the first one published
Instead of looking for its exercise enhancement, the extra energy it may or may not provide, I think I’ll continue to take it at moderate doses and see if it has an effect on metabolic disorders. Many of these increase with age and are easily measurable with a blood test.
Since you are interested, I have been on Retatrutide for seven months now (1mg MWF so 3mg per week for the vast majority of the time). I am certainly continuing to feel the effects of a reduced (but not suppressed) appetite, which is great since I am not tempted to over-eat anymore. I am still looking more or less the same from a physique standpoint. My resting heart rate continues to be higher by about 10bpm, which I have just accepted.
I have to get some blood tests of Wednesday with an endocrinologist so I can get my TRT prescription renewed, and will ask him to add some things to check to see if there is a noticeable change in my lab work.
I don’t know if you recall, but I had an echocardiogram once month after starting retatrutide and my left atrium measured smaller than usual (which is good in my case), so that could be a result of reta or a result of the technician just measuring it differently since there is always some variation.
Either way, I plan to be on it indefinitely. I just ordered a whole bunch more. I feel good.
To get back on topic, I am really starting to become more interested in SLU-PP-32. The anecdotes people have mentioned about improved lab work is really what catches my attention. Claiming more energy doesn’t really sway me but improved labs does.
I too have noticed a general increase in resting HR, about 6 BPM on average. I just got an Oura ring and my HR during sleep never gets below 73 and it’s only that low for a short time. I don’t know what my HR during sleep was before (didn’t have the Oura) but my resting HR while awake was around 68 pre Reta and now averages 73.
I am wondering if it has an effect on body temperature, which wouldn’t be so noticeable when the air temp is 45 degrees but could more pronounced in the middle of a heat wave. I also take febuxostat for uric acid, which could be a confounding factor, since fever is a potential side effect of febuxostat.
Your small bump in RHR seems a reasonable tradeoff if you’re getting a benefit from reta. For me, and my friends who have Oura rings, the lowest sleeping HR is much lower than the waking RHR. My resting RHR is typically in the low 70s, but my sleeping HR was in the high 50s at its lowest point. I have no idea how to interpret your high heart rate while sleeping, but perhaps others have experience or research with that.
Yes, this makes it more interesting, but I’d have to know the details of what blood work, the baseline, and new values. Let us know if you come across this!
Thanks for the update! Please share what lab updates you are doing and the results. Inquiring minds want to know : )
What made you decide to get an echocardiogram? I had my coronary calcium score evaluated, but not an echocardiogram.
I spent a few years with hypertension in my 20s doing stupid things, so my heart enlarged a little. Enough to scare me into becoming interested in health & longevity. I get annual echocardiograms now.
Have tried few and I get near zero effect on pain relief and exercise recovery from the peptides I’ve tried. Do you mind sharing which ones you think worked for you?
Do you have any side effects at that dose?(1mg every other day sounds interesting) I tried Reta a while back 5mg once weekly and was good for losing weight, but did make me tired (noticeably). And did you lose any weight at that dose, or you weren’t looking to lose weight?
Resting heart rate higher by about 10bpm. That’s my only side effect. It does not cause me any fatigue at all.
Let me refer you the long thread on “Pepetides and Bioregulators,” which has a wealth of information. You can find it with the search function. I quote my most recent post:
“For me, TB Frag (1-4) is more effective than TB-500, the final seven-AA sequence, and more effective than the full 43-AA peptide. Dosing Frag (1-4) at 500 mcg per day keeps me pain free for a month, and then I cycle off for a month, during which the pain relief continues.”