Yes, I’ve read that sloop can have thermogenic effects by boosting whole-body metabolism.
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Oh jeez, my bad… I mean’t mcg NOT mg!! Sorry!
Back to my original question, you said “got some in bulk powder”. Where did you find it sold as bulk powder?
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I have trusted suppliers for a variety of compounds. I think that is called a “trade secret” 
I hate watching videos so I ran it through https://www.summarize.tech/
Al is very knowledgeable but I wonder about some of the statements on human effects. Since no trials have been done in humans those effects would be anecdotal N-1. I don’t have a problem with that, it’s at least a start.
The doses he is recommending are quite low 100mcg and up to 600mcg for athletes, He states a few things that would require specific blood tests to know for sure, so I wonder who has done those blood tests? He suggests higher doses for people with mitochondrial issues. THIS ASPECT I WILL be testing on our daughter.
He also says oral use is effective but does not specify the format of the oral, solid/powder or liquid. And again no test evidence is presented. I will stick with liquid as this compound is not water soluble, which in everything else seems to affect bio-availability negatively.
He did a good job explaining a lot of concepts around mitochondria but I’m not qualified enough to know how accurate it is, so I’m going to “guess” he is not far off the mark or spot on. And I’ve learned a bit more on the topic.
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If this idea is outside the purpose of this forum, Admin, please feel free to delete this post.
I’m going to throw this out there…
Anyone who would like to do their own 60 day personal evaluation, I will provide product at no charge and only ask that shipping be covered.
I have not worked out an eval protocol. One aspect is that it will have to be in the liquid format.
Feel free to send me a DM.
Structurally it’s a pretty basic molecule and should be very easy to synthesize. Any organic chemist should be able to make this so I am not sure why it’s so expensive.
Synthesis
SLU-PP-332 is typically synthesized through a two-step process:
- Conversion of 4-hydroxybenzoic acid to 4-hydroxybenzohydrazide through esterification and subsequent hydrazinolysis
- Condensation of 4-hydroxybenzohydrazide with 2-naphthaldehyde to form the target hydrazone compound[3]
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I’ve seen chinese sellers sell it in bulk, it was way cheaper than that : 110$ for 5g.
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You could make a fortune!!
I checked them out… WOW! super high price
SLU-PP-332 Super-Extra Strong (30ml) 200mcg/drop
Regular price €324,99 EUR = $355USD
That sells for $80USD and with a higher dose (typical 250mcg) on most sites in NA
Several things affect the retail price of things. What it costs to make the raw/base material is not what drives retail pricing. That is just one factor of many factors that must be considered for any business to be successful.
I’ve seen a lot of business fail because they didn’t price to succeed. How retail prices evolve is as much a science as creating the compound itself. There are quite a few books on this topic.
I understand…I"ve been peripherally involved with a few startups and know what the budget of small companies are like.
My guess is that if this compound does turn out to be great, then some larger company will come along making kgs of material and take over the market. I see no intellectual property or other technical challenge given how easy it is to make (even I could have made this in grad school…LOL).
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I’ve done 4 startups, it’s not easy to get it right and I only got it right twice. I’ve also worked for 2 startups, one succeeded.
While failure is a great teacher, it still sucks LoL!
The research area of synthetic ERR modulators is growing as there appears to be potential for many age related benefits.
How to prove self-experiment interventions with SLU-PP-332 use
To do this little intervention we should try to generate some anecdotal data. Please feel free to suggest what can be easily measured that may indicate this compound is having an effect.
To conduct your own N = 1 trial (Number in trial = 1), here are the steps to follow;
To prove this intervention has an effect, we need to track the following data for a double set AB test (ABAB test)
Establish a baseline with 1 week of data prior to the evaluation.
- Daily measurement of XXXX – weight? skin thickness? blood pressure?
- Resistance exercise - curls? bench? grip?
- Endurance - time to failure? speed?
- Calorie intake, e.g. cronometer or myfitness pal
- Exercise METs, e.g. Whoop does this automatically
a. What Are METs, and How Are They Calculated? - Total sleep time, Whoop does this automatically
- Eyesight - (some reports of changes)
- Hearing - (some reports of changes)
- Presence of any illness or infection
- Body temp upon waking
- Physical performance increase - based on known past performance
REMOVE / REPLACE / OTHER / ADDITIONAL???
Your input on what to look for is appreciated.
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This is easy. I have years of data on my times in the hundred-yard dash. Admittedly, my personal best is not as good as it was before I incurred some injuries. If sloop can improve my current time by three or four seconds, I would judge that as a clear, unambiguous result.
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I would say temperature in the morning when you wake up? If it increases metabolism maybe it shows up.
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I’m adding the suggestions to the list.
Have 20mg tabs as oral absorbtion is very poor. Lab tested and verified.
Took 20mg, nothing. Workout same, no temp change. Titrated up to 80mg on same day. Still no effect.
Many report this does nothing and others it works great at 500mcg.
Maybe it works on some and not others. Sigh. MOTS-c doesn’t work on me as well.
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When you consider that most online vendors are selling 250mcg doses in bottles with 60 doses in the form of caps/tabs or liquid equivalent for $80US that means companies are selling 15mg (60 x 250mcg) for probably more than you paid for 1 tab…
This would cause me to question what exactly is in the 20mg tab?
There is 20mg of SLU-PP-332 in the tabs. The other sellers are juste surfing on the interest that it creates to make a lot of money.
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It’s Jano lab tested and is 19.5mg SLU-PP-332.
It’s either one of the many drugs that is over hyped by many YouTubers that usually sell this stuff or I am just a mitochondrial non responder.
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