This has been discussed in body building forums and they usually source their ped’s from China, so you can get reasonable 20mg pills from SSA. Others are getting lab tests completed, but I am sure it will fly off the shelves.
Many of these pop up, like 5 Amino1mq, AICAR, but never did anything for me when I researched them, including Sluup.
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Thank you.
But it’s so weird for a company to sell an expensive product, not invest money in marketing, and use a very basic AI logo. 
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Do we have any info on whether an oral formulation is absorbed at all?
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This guy, who really knows his stuff, recommends sub-mg doses to avoid overworking the mitochondria.
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Lol, I wonder if worrying about overworking your mitochondria is a completely normal behaviour. I have to admit, I am embarrased not to have thought of that. That said, wouldn’t that lead one to think, gee, I’d rather skip some molecule with no human studies or track record that forces me to worry about a wrong dose overworking my mitochondria!
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Most if not all substances, including food and supplements, have an optimal dosage level. Even water can kill you. Wouldn’t that lead you to think that, as a general policy, research is better than abstinence?
Definitely! But applied to something that has a bit more of a track record in humans. It’s really about risk reward ratio. Water and food are necessities. Substance X, which is not, requires a higher standard of acceptance. Overworked mitochondria pegs the risk side as pretty high (to me) - I’d look for a lot of reassurance and massive rewards.
I think Peter Attia liked to talk about picking up pennies in front of an incoming train vs stacks of $100 bills in front of a tricycle. Food and water strike me as the latter. However, we all have to make our own assesments of the risk/reward equation.
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He said the same thing about NDA.
“orphan nuclear receptors estrogen receptor-related receptors (ERRs) play an important role in skeletal muscle exercise capacity. Three ERR subtypes exist (ERRα, β, and γ), and although ERRβ/γ agonists have been designed, there have been significant difficulties in designing compounds with ERRα agonist activity”
does 17-alpha-estradiol activate it
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Have you looked into HMB for sarcopenia? …prevents muscle loss.
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I take BHB and HMB in my morning super shake 
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I’ve not seen solid evidence of HMB and muscle growth or preservation. I’ve been into weight training for decades and it seems HMB comes and goes as a supplement people use. Much better evidence for creatine.
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Ok…I’m just going on the studies and clinical trials i have read about and figured it was worth a try. Sorry for interrupting.
Or AAS. Get on some blood pressure meds and make sure your lipids stay where you want them. Keep the doses sane and don’t do it too often. Much better way to add muscle you can’t naturally and you get to keep a big percentage forever.
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Going to re-start my Sloop experiment next week got some in bulk powder . My main interest in this one is the effect that Sloop has on…
Upregulation of mitochondrial biogenesis through increased expression of TFAM (mitochondrial transcription factor A)
For the mitochondria folks @John_Hemming
The paper below is not on sloop but indicates the tie in with TFAM and the potential benefit for the brain,
The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms
https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.12989
Not sure if this Wiki was posted before but it has a lot of interesting info and links to papers.
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Great…Keep us posted!
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I wish I could measure any effect, other than by how I “feel” which is so unscientific 
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Where did you buy the bulk powder? This stuff gets a bit expensive if you have to get up to 800 mg’s a day (split) which seems to be where strongest effects are felt for many people.
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I have not seen anyone online claiming to use SLU at that volume. Not to say it hasn’t happened BUT… I have seen people using 1x 250mcg and 2x 250mcg and on up to 1,500mcg per day.
I’ve used 250mcg single dose per day when I first tried it. I didn’t notice much but my son noticed “heat”. But that was only a 30 day supply.
The typical retail products are capsules, pills and some liquids. They are selling 250mcg doses, 60 doses per bottle = 15mg total SLU in a bottle that the average retail appears to be $80 USD. Thats $5.33 per milligram.
An 800mg daily dose at that retail price would cost over $4,000 per day.
I don’t know much about this small molecule compound, other than;
it is not a peptide,
in the mouse trials it was injected intraperitoneal
in mouse trials it was administered at 25 mg/kg up to 50 mg/kg
in mice the oral bio availability is around 47%
is metabolized by hepatic CYP450 enzymes.
SLU-PP-332 is not water soluble
Using the common factor of mouse to human dose adjustment 25 mg/kg for a mouse equates to 0.081 x 25mg/kg = 2.0mg/kg. INJECTED… not oral… Which for me at 62kg would be a 124mg daily dose. At retail price, over $600 per day LoL!
Because it is not water soluble, using it orally in a solid format, powder or pill will significantly reduce it’s effect. The developers of this molecule are very aware of this and are working on a more bio-available version for human use.
It can be dissolved in DMSO and alcohol so my next experiments will be as a liquid. I will pe-disolve the SLU and then dilute with distilled water.
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