Hi, I’m a 60 yr old postmenopausal woman on HRT who started Rapamycin about 2 months ago and has had a 5mg once per week dose for about a month. I just started spotting and bleeding and I’m wondering what’s going on. I stopped Rapa for now. I have a history of Endometriosis and my period can be very heavy and last up to 3 weeks. The last one I’ve had was about 10 yrs ago and I have been in remission from Endo for a long time. Anyone else here who had something similar?
I was only in menopause for aprox 1 month (12 months + 1 month) and started again for a couple of months when I started rapa. It happened again a few months later, but that was all. I’ve seen this happen to others as well.
However, to be safe than sorry, I did go for a vaginal ultrasound to rule out cancer. If it had continued, I would have eventually had one more.
Thanks for you input! How long have you been on Rapa now? If it happens only once or twice in the beginning, maybe it’s worth continuing. However, if periods become regular, does not seem worth it to me.
I’ve been on it for aprox 15 months.
If you do cycle again, to me, that means your insides are younger, and that would be a great a reason to continue, albeit even if annoying. It’s definitely such a personal decision.
Happened to me too. I posted details about it on here if you search my name.
They are studying rapa for egg preservation in younger women, but it’s unclear what the outcome will be. One woman on this forum used rapa to try to retard egg aging but she reported that her tests may have indicated more rapid egg aging.
I was hoping that my sudden one time period signified rejuvenation of sorts, but now I wonder if it just exhausted the last reserves within my ovaries. Still hopeful that I’m doing more good than harm.
Oh, I also had a lot of breast tenderness that lasted for weeks which made me think my hormones were in flux.
You may want to review these threads, if you have not already:
I thought bleeding on HRT meant you need to raise the progesterone dose.
100mg micronized progesterone daily titrated up to 200mg as tolerated is considered the gold standard.
Here are the notes I’ve collected for my wife. She is just starting perimenopause I think.
LCMS ASSAY for tests!
Start with estradiol. Then add progesterone. Then add testosterone.
Systemic estrogen:
Transdermal estradiol twice weekly patches. Start low to avoid breast tenderness. Look at gels or SYSTEMIC rings if patches don’t work for you. Look for rings falling off the third month.
Local estrogen therapy:
local vaginal estrogen(2nd choice) or DHEA(preferably)
Vulvar vestibule needs both estrogen and testosterone
0.01% estradiol and 0.1% testosterone applied to Vulvar vestibule if needed
100mg micronized progesterone daily titrated up to 200mg if tolerated. (Do you bleed? You may need more.) Take it vaginally if oral sides are too harsh.
1% testosterone gel - 0.5cc (1/2 gram) daily
Never stop HRT!
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Thanks so much for your feedback, everyone. That was very helpful. Good to know about progesterone, but I have been on the same dose of progesterone for about 8 yrs with no breakthrough bleeding so I know it’s not the progesterone dose. However, it’s comforting to know that this happens to other people on Rapa. I’m so grateful for this forum, great way of exchanging info and supporting one another.
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