Minocycline is a very cheap medicine and useful in a variety of infections. It has shown some off label benefit in Multiple sclerosis and other conditions due to its ability to penetrate blood brain barrier… But it is a valid concern about superinfection and antibiotic resistance if used daily.
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Thanks for sharing this interesting document! Curious question, in what place did he share this document? Twitter post or some other way? I would like to find the source 
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I think it was sent out as part of his newsletter. I can’t find the newsletter though.
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Ok, If you find the source please share it here
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I found the monohydrate version of Doxycycline causes much less GI upset.
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Doxycycline is an interesting drug. Like a lot antibiotics, its effects don’t exclusively come from the direct action against bacteria. It also has significant effects on a number of inflammatory mediators like tumor necrosis factor and various interleukins.
Those anti-inflammatory actions explain why it is useful at doses below the minimum needed to inhibit bacterial growth. There’s a low dose version (20mg 2xday as Periostat or 40mg delayed release 1xday as Oracea) that was originally used for periodontal disease and was then found to help with rosacea, acne, and dry eye caused by meibomian gland dysfunction. This low dose has been shown not to affect the intestinal microbiome. Even the 50mg dose of doxy has some negative effects in that regard, so 40mg a day is right at the threshold.
There may also be some benefits for atherosclerosis/CVD. There’s not a ton of evidence on that front, but an interesting possibility.
Some selected articles of interest:
https://sci-hub.st/10.2174/157489011794578419
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To ward off arthritus I have taken one doxycycline a day for the last 30 years. Arthritus was common in my family and my wife has suffered for years. At 72 I can still work (more slowly) a full day with no arthritus. Been on Rapa 4 years with varied doses and schedule. Happy to read of others’ experiences. Dr. Green’s patient #139
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Is that a 40 mg dose once a day?
Danthemason, at what dose?
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100mg So I’ve got to use 20 characters .
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I was surprised and puzzled to see posts regarding the use of doxycycline as part of longevity protocols. One of my areas of interest regarding health and aging is the human gut microbiome. I recently wrote a paper titled The Microbiome Theory of Aging, which was published in the January 2023 issue of the peer-reviewed journal Integrative Medicine. In this article I explain how microbial imbalance (dysbiosis) causes inflammation and intestinal permeability, which ultimately cause tissue and organ damage and the acceleration of biological aging. The gut microbiome regulates many aspects of health and I cannot imagine how taking an taking an antibiotic regularly could promote healthy longevity.
Here is the open access link for my article on The Microbiome Theory of Aging
Warm regards, Ross
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From the Mayo Clinic. A list of Doxycycline side effects;
Incidence not known
Blistering, peeling, or loosening of the skin
bloating
chills
clay-colored stools
constipation
cough
dark urine
decreased appetite
diarrhea
diarrhea, watery and severe, which may also be bloody
difficulty with swallowing
dizziness
fast heartbeat
feeling of discomfort
fever
headache
hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
hives or welts, itching, or rash
increased thirst
indigestion
inflammation of the joints
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
nausea
numbness or tingling of the face, hands, or feet
pain in the stomach, side, or abdomen, possibly radiating to the back
red skin lesions, often with a purple center
redness and soreness of the eyes
redness of the skin
sore throat
sores, ulcers, or white spots in the mouth or on the lips
stomach cramps
stomach pain or tenderness
swelling of the feet or lower legs
swollen, painful, or tender lymph glands in the neck, armpit, or groin
tightness in the chest
unusual tiredness or weakness
unusual weight loss
vomiting
yellow eyes or skin
In my thirty years of taking Doxycycline, 100mg, once a day I have had none of the listed reactions. In reading over the MTA paper, there remain many unexplored and confounding interactions that only years of research could hope to untangle. For your consideration this 72 year old mason still works and enjoys a full life. N=1 studies are meaningless I understand. But here I stand.
Daniel R Murray
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A list of side effects; meaningless!
Real human proof is what you follow!
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Hi Daniel,
I’m certainly glad to hear you don’t experience any of the listed possible side effects from taking Doxycycline. One thing that is not included on that list is changes to your gut microbiome. However, I’m certain that taking Doxycycline is killing off many of the beneficial probiotic bacteria in your colon, resulting in some level of bacterial imbalance. That said…I’m glad you are still going strong at age 72.
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I will remain skeptical of your certainty…
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What was the reason for you taking Doxycyclin for 30 years? Was it recommended by a doctor?
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I am wondering about this reason for the combination of the two drugs. I suspect its so that the company behind the combination can patent this unique formulation, with the rationale that rapamycin can in some situations suppress the immune system so why not combine an antibiotic… Perhaps and overly simplistic take on it, but we will see.
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The creation and maintenance of a healthy microbiome is essential for healthy longevity. I believe that taking an antibiotic regularly will upset microbial balance, reduce the production of important health-regulating postbiotic metabolites and cause some degree of intestinal permeability. These are NOT good things to have happening…
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I can speak to minocycline, nearly identical to doxy, which decreases inflammation in the brain. We are having a gazillion micro ischemic changes in the brain as we age, and the Rapamycin, with its known potential benefits, combined with a brain inflammation reducing agent, like minocycline and doxycycline, together might work synergistically.
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Totally agree on not wanting to upset the gut microbiome, though I wonder if having been on the Doxycycline for several years if the microbiome has become totally resistant to it.
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