Peptides / Bioregulators

I’m aware. I’m discussing it here because I searched for the compound and this was the only place I found it being discussed.

A thread on ERR modulators could be a good place to start.

I appreciate you bringing it up.
Even though SLU-PP-332 is NOT a peptide, it is commonly categorized as such and almost 99% of people that would dabble in ERR would be peptide users.
Thus, I believe it to be a valuable addition to this thread I started way back when.

Please continue to share any research you are doing with SLU-PP-332 etc and any results, affects etc.

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Last week, Eli Lilly filed six US lawsuits concerning the alleged unlawful sale of retatrutide.

It’s interesting that they are suing companies that apparently no one has heard of. Not sure what their strategy is, but it may in part depend on vendors who are careless in advertising and careless in their dealings with customers (providing email evidence for instance that they know customers are self-injecting the product, giving them customer support helping them do this, etc).

I don’t know, but I stocked up on reta months ago.

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That was my starting dose. I now dose around 1.2-1.5mg every 3 days. I was very sensitive to TA-1 initially but not anymore after using it for awhile.

The GLP-1–Mitochondria Axis in Metabolic Aging

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.70676

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But loading up on NAD+ isn’t universally recommended.

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Neither is using Rapamycin, it’s a personal decision for now.

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Do you really think the majority of people using peptide care what the opinion/stance of the FDA is?

The FDA is really Failure, Deception, Abuse {as was coined 20 year ago].

This caught my eye today and I asked Perplexity if there is a peptide that would help.

Here is the result, some of our favorite peptides may be helping to mitigate sarcopenia.

any peptides that may help with sensory conduction.pdf (541.2 KB)

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Hopefully, some entity will find it in their interest to fund research.

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From its responses, perplexity seems to be assuming your question is directed at nerve injury from trauma rather than aging. I’d consider re-asking the question and specify nerve degeneration from the aging process.

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from Max Swiergol | Research-Based Health on X: "The University of Arkansas just launched the 1st U.S. based injectable BPC-157 Randomized Controlled Trial for tissue healing. They’re studying post-rotator cuff surgery healing through objective measures like strength testing, MRI, and range of motion. … / X

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Full podcast here:

https://www.wsj.com/podcasts/the-journal/why-chinese-fentanyl-factories-are-making-peptides-now/f198ab89-8d45-4923-8904-e9a42f7b550c

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This looks like the original source: Americans Are Buying Peptides From the Same Chinese Chemical Vendors Selling Fentanyl Precursors: Sales Up 32% Since 2023 | TRM Labs

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I thought it was interesting, and brilliant, that Brian Johnson has gone all in on online healthcare.

Most of us have much less expensive sourcing for peptides, but for someone who had no other options and wanted to pay with a credit card, I’d trust his product. He’s also offering other rx’s. Genius!

https://immortals.com/pages/immortals-medicine

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Be careful with the greymarket / black market:

The Food and Drug Administration received reports in recent months that two people died after taking bootleg versions of an experimental weight-loss drug, according to documents reviewed by CBS News.

The reports link the deaths to products claiming to be retatrutide, a drug being developed by Eli Lilly that hasn’t been approved by the FDA. Federal lawprohibits the commercial sale of unapproved drugs, but that hasn’t stopped vendors from selling imitation versions of the experimental drug online at a scale with no modern precedent.

The cases appear to be the first public accounts in the U.S. alleging that unauthorized use of retatrutide — or products claiming to contain it — played a role in a patient’s death, though the details aren’t verified and it is unclear whether the drug was to blame.

The first death reportedly occurred in July, when a healthcare professional informed the FDA that a 41-year-old woman with obesity went into cardiac arrest. The report lists retatrutide as a “suspect product,” noting the woman had obtained it “from an unreliable source.”

Then in September, the FDA received a report that a 49-year-old patient died after a licensed nurse “convinced” her to buy retatrutide from an online peptide vendor and she experienced severe dehydration, malnutrition and cardiac arrest.

Though the reports alone don’t prove that the drugs caused or contributed to patient deaths, they point to the potential dangers of an illicit market for unapproved drugs like retatrutide.

“It is concerning because of the breakdown of our drug-approval process in the United States of America,” said Pieter Cohen, an associate professor at Harvard Medical School.

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even treatments with substantial benefits carry risks, including authentic pharmaceutical products. A recognised brand, controlled manufacturing and a prescription provide safeguards; they don’t remove every risk.

Untested grey-market peptides add uncertainty about what is actually in the vial. Harm could arise from its contents, the compound’s biological effects, or interactions with the patient’s health and other medicines. Some of those reactions could also occur with a branded product. Determining the cause requires investigation of both the product and the clinical circumstances. The source alone does not establish why someone became ill or died.

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No drug or therapy is “risk free”, but there is a large difference between the relatively well known and well-tracked risks of US / European / Japan pharma company manufacturing processes (tracked, quality controlled) and the largely unknown risks associated with many grey market and black market suppliers. Its good to be aware of what types of risks you are taking… are they the “known unknowns” or the “unknown unknowns”…

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