Approximately 200mcg per spray (20mg of active compound per bottle) At 6mg per day this doesn’t seem feasible.
Supposedly more bioavailable nasally. I notice a little bit but not that much when using.
A recent short YouTube video from Dr. Matt Kaeberlein. I won’t summarize it because it is quite short. And yes, I tend to be an early adopter of “shiny objects.”
Expresses my thoughts exactly, especially after the fact that I tried several injectable peptides over a period of months without any subjective or measurable benefits from most.
The exceptions were tirzepatide and N-acetyl semax nasal spray.
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Tired many but only a few peptides had noticeable impacts:
Tirz and Reta - major impacts visibly, on scale, in many labs; which led me and many others to hope other peptides would have similar or even part of the degree of impact … none have come close but a few have been noticeable.
Semax - initially impact was more significant, you simply notice it. Perhaps not as much as anticipated from that initial feeling though.
Tesamorelin / Ipamorelin - measurable labs and waist size reduction. Dexa scans not close enough to correlate with this cycle but potentially visceral fat reduction related to this.
GHK-cu - topically I’m skeptical but it doesn’t hurt, injected give minor skin improvements but not noticeable reduction in loose skin.
Maybe some benefit from TA-1 (family all got flu and colds but I stayed healthy), BPC and TB4 (hard to tell if injured would have healed as fast or recovery as fast if done without them - didn’t resolve old injuries).
Over 10 other peptides and SARMS and NAD: nothing noted from labs, scale, or subjective feelings.
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I wasn’t sure where best to post this.
But this is an intriguing longevity protocol, that if valid, puts rapamycin to shame.
Hi, I typically use this protocol here Using AI for Health and Longevity and Research - Your Favorite Prompts - #17 by RapAdmin
do evaluate a transcript of the video, to save time and to fact-check the claims.
Here is the result from ChatGPT:
A. Executive Summary
This episode features Dr. Bill Lawrence presenting long-awaited results from an 8-year telomere study and a 5-year epigenetic (DNA methylation) study evaluating Russian-discovered bioregulator peptides. Trained directly under Professor Vladimir Khavinson, Lawrence situates his work as a U.S.-based confirmation of decades of Soviet and Russian clinical research originally developed for military, spaceflight, and occupational health resilience.
Bioregulator peptides are short, organ-specific amino acid sequences derived from animal tissues that allegedly home to corresponding human organs, modulating gene expression, DNA repair, and tissue regeneration. Lawrence argues they act as normalizers, not stimulants—restoring youthful cellular function rather than boosting or suppressing systems.
Central claims include:
- Dramatic mortality reductions (up to ~50–60%) in elderly populations using pineal and thymus peptides alone;
- Organ regeneration, including retinal tissue in degenerative eye diseases;
- Biological age reversal or deceleration, measured via telomere length and increasingly granular epigenetic clocks assessing up to 19 organ systems.
Lawrence emphasizes that pineal and thymus peptides consistently outperform others, calling them foundational to all protocols. He reports that oral natural peptide extracts, while slightly less potent than injectable organ extracts, retain ~90% of their long-term telomere effects and are suitable for multi-year use.
Importantly, observed benefits reportedly require long durations (1–4 years), contrasting with fast-acting synthetic peptides. Lawrence frames the intervention not as “anti-aging” but as system-wide repair, aligning with Khavinson’s view that aging cannot be reversed wholesale but can be profoundly modulated at cellular and epigenetic levels.
B. Bullet Summary (15–18 bullets)
- Bioregulator peptides originated in Soviet military and space medicine during the Cold War.
- Peptides are short amino acid chains (2–4 AAs) derived from specific animal organs.
- These peptides are claimed to be organ-specific via receptor “docking” mechanisms.
- Pineal and thymus peptides were the first discovered and remain the most impactful.
- Russian trials showed ~50% reductions in mortality using only pineal peptides.
- Combining pineal + thymus peptides further reduced mortality in older cohorts.
- Effects were observed even when peptides were administered for only ~3 years.
- Lawrence launched U.S.-based confirmation studies beginning ~2017.
- Biological aging was assessed using telomeres and DNA methylation clocks.
- Epigenetic testing evolved from single-age outputs to multi-organ aging profiles.
- Newer labs claim direct measurement (not prediction) of organ-specific aging.
- Protocols are adjusted based on accelerated aging in specific organs.
- Oral natural peptide extracts are ~90% as effective as injectable extracts long-term.
- Synthetic peptides act faster but are less suitable for long-duration longevity goals.
- Peptides appear to normalize function rather than stimulate or suppress systems.
- Claimed mechanisms include restoration of DNA repair systems.
- Reported organ regeneration includes retinal tissue in degenerative eye diseases.
- Meaningful results typically require 1–4 years of consistent use.
D. Claims & Evidence Table
| Claim | Evidence Presented | Assessment |
|---|---|---|
| Pineal peptide reduces mortality by ~50% | Russian elderly cohort studies (12-year follow-up) | Speculative (extraordinary effect; limited independent replication) |
| Pineal + thymus peptides reduce mortality to ~33% in ages 75–89 | Russian “old people” study | Speculative |
| Bioregulator peptides are organ-specific | Animal-derived peptide homing observations | Weak–Speculative |
| Peptides restore DNA repair systems | Khavinson-published studies (not detailed here) | Weak |
| Oral peptides are ~90% as effective as injectables | Internal telomere comparisons shared verbally | Unsupported (no published data shown) |
| Retinal degeneration can be reversed | Visual field imaging examples; anecdotal cases | Weak–Speculative |
| Telomere length increases after peptide use | Lawrence’s 8-year study (data not shown yet) | Speculative |
| Epigenetic age can be reversed or slowed | 5-year DNA methylation data (not shown) | Speculative |
E. Technical Deep-Dive (Relevant)
The proposed mechanism centers on epigenetic modulation and DNA repair normalization. Khavinson’s hypothesis suggests peptides bind nuclear DNA regulatory regions, influencing transcription and improving fidelity of DNA repair machinery. Improved repair theoretically reduces mutation burden, stabilizes telomeres, and restores tissue-specific protein expression. This places peptides upstream of many aging hallmarks—but this remains mechanistically under-characterized in Western molecular biology terms.
F. Fact-Check of Important Claims
- Mortality reductions of 40–60%: These figures far exceed effects seen with any validated longevity intervention (e.g., statins, caloric restriction mimetics). Independent replication outside Russia is lacking.
- DNA repair “restoration”: No widely accepted evidence shows peptides can globally reset DNA repair systems in humans.
- Retinal regeneration: Conflicts with current ophthalmologic consensus; extraordinary claim requiring randomized controlled trials.
Bottom line: The claims are biologically intriguing but extraordinary, and currently rest on limited-access Russian literature, unpublished data, and anecdote. Independent replication, peer-reviewed U.S./EU trials, and mechanistic validation are essential before acceptance into evidence-based longevity medicine.
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I’m more inclined to think of most if not all of the “bioregulators” as a scam, but if future research proves differently then I’ll be happy to change my mind.
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People often talk about academic fraud, jinky papers, big pharma, etc, in western medicine and research and yet they take Russian BS at face value. The unknown and exotic promise appeals to many people.
Kavinson appeared to be appealing to the oligarchs desire to live forever and he seems to have failed in that endeavor. How much time and money did he suck out of them?
There is a different level of consequences in Russia for failure to the state and it’s rulers. How many shining Russian stars, in a wide variety endeavors, have fallen from a window or committed suicide with 2 bullets, drank the wrong tea, etc.
One thing that blows me away are westerner’s moving to Russia so they can live a “fundamental christian life”, guess they can’t read history books or see what has been going on there for the past 85 years.
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[quote=“Steve_Combi, post:940, topic:11956”]
Kavinson appeared to be appealing to the oligarchs desire to live forever and he seems to have failed
“Despite his claims and reported promises to the Russian elite, Khavinson’s death at 77 was widely viewed as a failure of his own theories for several reasons:
Failed Longevity Projections: Khavinson had publicly stated that human life could be extended to 110 or 120 years through his peptide bioregulation methods. He personally used his own peptide complexes for over 30 years and intended to live past 100.
“Putin’s Gerontologist”: He was known as the personal longevity expert for Vladimir Putin and other members of the Russian political elite, allegedly promising them methods to significantly extend their biological “ruling life”.
Scientific Skepticism: While he introduced “Gerontology and Geriatrics” as a specialty in Russia and held numerous patents, critics often compared his peptide extracts—derived from animal organs like bovine liver or eyes—to homeopathy and questioned their scientific efficacy.
Cause of Death: While his death was reported as “sudden,” no official cause of death was disclosed to the public.”
Being too near Putin is always risky business.
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A new peptide, VD11, promotes structural and functional recovery after spinal cord injury
“The regenerative capacity of the central nervous system is very limited and few effective treatments are currently available for spinal cord injury. It is therefore a priority to develop new drugs that can promote structural and functional recovery after spinal cord injury. Previous studies have shown that peptides can promote substantial repair and regeneration of injured tissue. While amphibians have a pronounced ability to regenerate the spinal cord, few studies have investigated the effect of amphibian spinal cord-derived peptides on spinal cord injury. Here we report for the first time the successful identification and isolation of a new polypeptide, VD11 (amino acid sequence: VDELWPPWLPC), from the spinal cord of an endemic Chinese amphibian (Odorrana schmackeri). In vitro experiments showed that VD11 promoted the secretion of nerve growth factor and brain-derived neurotrophic factor in BV2 cells stimulated with lipopolysaccharide, as well as the proliferation and synaptic elongation of PC12 cells subjected to hypoxia. In vivo experiments showed that intravertebral injection of VD11 markedly promoted recovery of motor function in rats with spinal cord injury, alleviated pathological damage, and promoted axonal regeneration. Furthermore, RNA sequencing and western blotting showed that VD11 may affect spinal cord injury through activation of the AMPK and AKT signaling pathways. In summary, we discovered a novel amphibian-derived peptide that promotes structural and functional recovery after spinal cord injury.”
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ARA-290 (cibinetide) is another peptide used in the “research community” for neuropathic pain, peripheral nerve degeneration and inflammation, although it requires daily injection (like SS-31) until they further develop the longer-acting modified version:
Turns out it also may have some anti-aging properties if the research hold up in humans:
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BTW here’s a brand new video from two physicians I respect a lot. Their views on most peptides are pretty conservative yet overall quite reasonable IMO given the lack of clinical trials for many of them (it all depends on one’s risk tolerance).
Regarding the section on GH secretagogues, one thing I’m still trying to figure out is the apparent huge disconnect between the published research on the anabolic effects of human growth hormone (which is underwhelming at best) and real-world use of GH, which has been a staple for decades along with testosterone for professional bodybuilders. It can’t just be a placebo.
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Agent Smith, for those of us who are fairly unknown to the peptide world, how would you suggest we get some reputable vendor information? Some of us on this forum were drawn here initially to try to figure out how to find a reputable source for rapamycin. Peptide sourcing seems fraught with plenty of potential pitfalls and problems.
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I don’t have time to watch the video, but do you know offhand the doses and durations that have been studied in healthy adults? I don’t think we can learn much from AIDS patients or idiopathic short stature.
I can at least describe Broderick Chavez’ theory, which is not that it directly stimulates muscle tissue growth, but (1) keeps tendons, ligaments and bones strong enough to sustain heavier loads and muscle strain (i.e. facilitates recovery via repair), (2) the water retention in the cells, the actual pressure, creates growth signals, (3) the nutrient partitioning, when combined with AAS and insulin drives nutrients into the cells, (4) it might cause hyperplasia. But we’re talking about 6-15+ IU a day and IGF-1 off the charts.
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It is a bit more difficult with peptides as vendors come and go all the time. There are many Chinese vendors of these peptides that provide affordable pricing. I’d be interested to hear from someone who has a better suggestion than buying peptides and having them tested which can be a bit pricy.
Here’s a key study where they combined GH (2 IU/day) with resistance training in elderly men. No effect on strength or hypertrophy above resistance training alone, but lots of side effects.
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Here’s a review paper that sounds a bit more positive. GH clearly reduces body fat mass and increases lean mass, but from other papers it appears that most of the lean mass gains are from water and non-muscle tissue.
GH may shine more in the area of preserving lean muscle mass during caloric restriction rather than directly building muscle.
This is the kind of nuance that I think is missed by those who dismiss GH or GH-releasing peptides as worthless just because they don’t make muscle “grow” per se.
In theory at least, combining GH or a GH secretagogue peptide (tesamorelin) with a GLP medication would both enhance fat loss and at the same time help prevent loss of lean muscle tissue. Would be great to see a study combining two FDA-approved peptides, tirzepatide and tesamorelin, to investigate this.
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Yup, I’ve seen these studies also, and HGH at replacement doses and the GH related peptides do just cause water retention and will increase lipolysis. Though once insulin sensitivity degrades they begin to work against you, and they’re definitely not anabolic. The nutrient partitioning helps with body composition.
I have stopped HGH and may not touch it again because I don’t like seeing my cystatin C shoot up 20-30% even if it might just be the HGH acting directly to cause the increase. I’m unwilling to take the risk that it’s straining my renal system because of fluid and sodium balance.
I completely agree that the peptides shouldn’t be dismissed, as the growing consensus is that they are very useful for recovery and fat loss, and may be safer to cycle than HGH. Tesamorelin is powerful, and will reduce visceral fat in particular (also some subcutaneous fat), though it can cause more insulin resistance than others. Hexarelin is short acting, very strong, but spikes cortisol. It is best used during the day. Ipamorelin is a solid choice that pairs well with tesamorelin because of their synergistic mechanisms. CJC seems a bit weaker, but is safer than tesamorelin and also pairs with ipamorelin.
What I’m not aware of are any studies in healthy men at bodybuilding doses if HGH, but I have seen the photos before, during and after high HGH cycles, after the water has dropped back off, and pros swear by it. Clearly something different is happening at 6+ IU.
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After helping many people find their way into the peptide world, I’ve come to share the belief often repeated on steroid forums that “spoon-feeding” sources to people isn’t helpful to them in the long run because they don’t actually learn what they need to know in order to navigate the world. So I think the question you’re asking is very much the right way to ask it: how can one find reliable information?
The way I did it was I spent hundreds of hours on different forums until I found discords and telegrams that led to more discords and telegrams and WhatsApp groups.
It is easier now than ever, though. What you need to do is go to these forums and just read and read and read.
www.thinksteroids.com (meso-rx, focus on the Underground)
PepChat – Home of the Peptide Community
https://glp1forum.com/
Those will get you started. Reddit is a waste of time and is filled with misinformation confidently repeated.
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