Ora Biomedical Million Molecule Challenge Results

[John_Loverich]

Saw it claimed that Cyrene provides 75% lifespan increase (preprint)… though also suggests caffeine should work well from older experiments Cyrene: A Novel Geroprotective Compound that Extends Lifespan and Healthspan in C. elegans and Drosophila - PMC . Some of the data from previous studies they show further down doesn’t seem consistent with ora results.

[AustraliaLongevity]

orforglipron.
Oral glp1

Also myo Inositol trispyrophosphate

[PolishGentleman]

@Krister_Kauppi: @Curious: @adssx:

What is the current longest living lifespan of C Elegans from Wormbot or other testing platform?

– From what I’ve found:

• Placebo: 22.9 days

• Carvedilol 50uM + Doxycycline HCl 50uM: 27 days (adssx)

• Sulforaphane 50uM + Nilvadipine 10uM: 27 days (adssx)

• GSK2126458 : 27.8 days (Krister_Kauppi)

• Doxycycline HCl + GSK2126458: 33 - 34 days? (Curious)

• Doxycycline HCl + lithium : 34 days (Curious)

Do we have any better results?
(from what I’ve found Ora database is not updated regularly - it doesn’t has these combinations yet on leaderboard)
https://orabiomedical.com/mmcleaderboard/

I wonder what would be the result if we would test this combination: Doxycycline HCl + lithium + GSK2126458

[adssx]

@PolishGentleman

(from what I’ve found Ora database is not updated regularly - it doesn’t has these combinations yet on leaderboard)

They told me a few days ago that they will update it…

[PolishGentleman]

Also Epiterna did experiments similar to Wormbot:

• GSK2126458 + Doxycyline: 40 days
• GSK2126458 + LY-294002 41.5 days

It seems like PI3k inhibitors work best in C Elegans - in 2008 some study found 900% lifespan extension with PI3k mutation (160 days median lifespan):

900% lifespan extension with PI3K-null mutations in worms

PI3K-null mutation in worms can extend lifespan by 900% (article from 16 years ago) We now find that, after prolonged developmental times at 15-20 degrees C, they mature into extremely long-lived adults with near-normal feeding rates and motility. They survive to a median of 145-190 days at 20 degrees C, with nearly 10-fold extension of both median and maximum adult lifespan relative to N2DRM, a long-lived wild-type stock into which the null mutant was outcrossed. PI3K-null adults, although a little less thermotolerant, are considerably more resistant to oxidative and electrophilic stresses than worms bearing normal or less long-lived alleles [pi3k null mutations]

[Krister_Kauppi]

I like that you look att total days but its important to also take inconsideration that the lifespan on the control group can differ between the treatments. If I remember it right then Ora has observed that the worm lives a bit longer then now compared to what they did. So if we only look at total days lived then the comparison between compounds can be misleading. Just something to keep in mind but I like your list!

@adssx Thanks for the update!

[Krister_Kauppi]

I have added the epiterna data to the LID database. My plan is to add also the Ora data there as well this year.

https://rapamycinlongevitylab.com/lid