[we] worked with the research team and they also had flagged that the controls were long lived for the compounds dissolved in H2O (H2O controls) on this set of experiments and had already launched a repeat by the time the report containing the original run was sent to you. Our lab manager had found used manufacturer supplied H2O for the original set of experiments but had found that it drastically extended lifespan across several experiments. While we haven’t performed chemical analysis of the stock yet, we believe it was contaminated and not pure H2O. Our lab manager initiated a repeat of the experiment with internal H2O stocks that we generate with a water purifier and then sterilize via autoclave. This repeat (data attached) had controls in-line with what we would expect for the conditions tested and similar lifespans for the compounds tested in both experiment 1 and experiment 2 (the repeat).
Our apologies for the internal communication issue - a note should have been added to the original report indicating that we were performing a retest of the experiment
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The good news with this update: high-dose TUDCA and high-dose sodium citrate dihydrate look OK. Not as good as UDCA though: Ora Biomedical Million Molecule Challenge Results - #452 by adssx (Poke @John_Hemming @Davin8r )
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I continue to worry about the reliability of tests on live food.
Thanks so much for contacting them and for sharing the results! Those results look a lot more within expectations too.
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