not at low doses. apparently, there is some people on these boards that haver been taking doxy 100mg for last 20 years and they said they’ve had no issues. I myself take it only two days at 100mg, then at 25-50mg which is considered sub antibacterial. Actually I’ve only been doing it this way continuously for last three months, but I used to take it 100mg with Rappa for last 3 years on and off and. so far nothing good or bad that I can tell other than no infection of any kind. BTW, I consume a lot of cultured/butter milk and that is believed to help with gut microbiome. Yogurt and kefir are also good but don’t like the taste of either, and really like the taste and texture of buttermilk, plus it is easy to make my own. When I’m about 80% through the container, I just fill it with organic milk, mix it a bit, and leave it out of fridge for 10-12 hours. Walla, perfect buttermilk/kefir in never ending supply LOL.
Thanks for sharing your comments. Well, in my specific case of infection (which was a one-off occurance 2 years ago), the GPs and the clinician at the hospital used all these terms interchageably (sebaceous cyst, abscess and UTI), although I’m not sure what could have led to what. I had symptoms of UTI, along with presence of cyst, infection that was dominant in the pelvic region, however, it was systemic as well (feverish symptoms on a persistent basis for about a couple of weeks).
I have been on rapa for about 2.5 yrs now (been taking it cyclically). Except for very mild ulcers (which only occured a couple of times in my early days of staring on rapa), I never faced any issues… except during that one-off phase 2 yrs ago when I added empagliflozin. It wasn’t a coincidence at all, it was quite obvious to me that my body doesn’t do well when empagliflozin + rapa is taken together.
My A1C toggles between 5.4 to 5.7%, which I’m keen to optimize. It appears there is a strong case that SGLT2i is more effective and more promising that metformin, and has benefits beyond glucose control.
At some stage in the future, I’ll re-experiment adding back empagliflozin (perhaps when I’m cyclically off rapa), titrating carefully and see how it works out.
I’ll also analyse notes from @RapAdmin above.
Is this accurate (most people)? I am not challenging - genuinely new to this. I have some antibiotics stored away, but was not taking anything weekly.
I don’t think thats accurate at all - I think it’s only a small percent of people who take rapamycin who also take doxycycline. I think a small micro-trend might have started in this area when Peter Diamandis started doing it a few years ago (I think he’s now stopped): Peter Diamandis Longevity Protocol: Weekly 6mg Rapamycin + 100 mg Doxycycline
I do keep doxy on hand just in case I get an infection, but I’ve only used it once in 6 years of rapamycin dosing.
I believe one of the issues with frequent dosing of doxy or any other antibiotic is this: One course of antibiotics can change your gut microbiome for years (New Scientist)
Personally, I wouldn’t do it.
Meant to use “some” of us not most. I only know 4 of us already and four is definitely not most LOL. I’m sort of intrigued though by Doxy, especially at sub antibacterial doses. There is some literature on its benefits, and I believe one of our docs (at least) on here has supported it.
I am Microdosing terzepatide. I am planning to titrate up to 1.25 if no issues arise and am at .75 currently. Normal Starter dose is 2.5. My understanding is that bone remodeling occurs overwhelminging as a consequence of weight loss and I don’t plan to lose much weight. I have already seen a meaningful effect on my glucose and am taking it for Long Covid as well as cardiovascular effects secondary to glucose. I am using a CGM to monitor the glucose effect. I have read it is the length of time at higher values (some use 140 or above) that have negative cardiovascular effects and that a CGM is the way to look for those spikes. My HbA1c is below pre diabetic. My genetics predisposes me to spikes.
I recommend checking the CGM readings with a finger prick glucose meter. In my experience the CGMs can be pretty far off the mark.
It actually gave me systems of worse than long covid LOL, I understand the lowering of glucose part but maybe not the best idea for long covid.