Hey Steve… I think my initial weight loss for muscle came with TRT for a year.
Then, I started rapamycin 6 mg weekly… -and after 3 months of weekly 6mg lost 25 pounds of visceral fat… just vanished. DEXA showed no fat there. Body used it.
Veins popped and I can eat non-stop
I think Jardiance is protecting me from my sugar and salt intake. Feeling great 
_
Yes, but it has a double nature. An antioxidant in the blood, it can turn into an oxidant in the cells. High levels are linked to gout, inflammation, and worse.
I use febuxostat to keep my uric acid at 4.5. The stuff I get from India is legit.
I took 12.5 mg Empagliflozin daily. I started losing weight each week. My body compensated with greater appetite. I switched to Dapagliflozin and this went away. My HBA1C did not change under either treatment. I have not had any noticeable side effects other than sometimes it burns when I pee. I assume there is some increased bacterial count accounting for this.
And just to add to that:
by nature of the clinical trials available, the best evidence exists for kidney protection and non-ASCVD related heart failure (i.e. heart failure not caused by ApoB/LDL related heart attacks). We got hard clinical outcome data out of RCTs.
For most people in this forum, the heart failure aspect may not be that interesting. The prevalence according to most recent NHANES data for the USA is 1,5% in the general population - reaching up to 13% in the very elderly >80 years of age. But these are almost all people with decades of exposure to known risk factors such as high blood pressure. A person with average blood pressure, not obese etc. has a very low lifetime risk up to age 100.
More interesting for everyone is the kidney protection aspect:
even in people doing everything right (in the “normal” range of things), kidney function is declining by about 50% from mid age around 40 to old age above 80. And there doesn’t seem to be a floor - centenarians experience continued decline, eGFR qualifying for kidney transplants in your regular 60 year olds.
So most people (almost all) in this forum can expect to experience this development. The mechanisms of kidney protections seems plausible, too - essentially reducing wear-and-tear in the kidneys through a mechanism specific for the kidneys. Similar to lowering LDL and blood pressure to very low levels to stop ASCVD.
…its primary indication of glycemic control in diabetes which can be extended to prevention of prediabetes progression to diabetes (we have studies) and glycemic control in general. For people here this too is useful, as quite a few here have prediabetes (myself included) or are struggling with glycemic control.
Stepping outside of RCT trials and looking at multiple obsevational studies, some pretty large scale, I personally am intrigued by persistent and strong associations with neurological health. I roll the dice with these drugs (empagliflozin in my case) betting on this association being actionable in NDD prevention and/or amelioration. I hope my bet pays off.
Did you ever get your Cystatin-C checked? It’s an easy add-on and will actually give you a valid measure of eGFR (kidney function). Creatinine is essentially worthless for guys like you and me who resistance train and take creatine every day.
Creatinine is essentially worthless for guys like us!
Exactly 
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I’ll let you all know in a few months. I started taking dapagliflozin 5mg in the am. Arcarbose 25mg at evening meal and 500mg metformin at bedtime.
