Maximum, I hope your recovery has been awesome and no bumps in the road for you. Safe Journey.
You are probably getting excellent medical care, but my 2 cents, for thought. I am good at this I think! Maximal Statin tolerated, Rosuvastatin 40 mg daily and fck the “side effects.” Less than 5% get muscle aches, but the Nocebo (reverse of Placebo, Negative side effect that isn’t there) is 35-40%. THAT, COVID Vaccines and the Patient Portal is proof god hates doctors!!
Very safe and in their case your best friend for the rest of your life. Do not use weaker statins like pravastatin or red yeast rice, If your doctor isn’t prescribing this, I would look for a new doctor. Also, evidence shows the benefit of Aspirin 81 mg daily for CAC over 100 outweighs the risk of bleeding, etc. Addition of Ezetimibe is good thought as well, although outcome data is lacking. If that does not bring your LDL below 70 then add a PCSK9 Inhibitor. Also a must for the 5% in your situation that cannot tolerate statins. I know the Drive is big on Lp(a) testing but this is not affected by any current treatments, so of no additional value. Apolipoprotein B is valuable since it tells you your LDL partical size and should be below 70 after treatment.
This is what I would do and does not represent personal medical advice to you. I would be extremely aggressive in lipid management since you have very valuable information about your health with the CAC score.
You can still play with Sirolimus but I would avoid testosterone supplementation if it isn’t necessary.
This is what I would do, but I am not giving direct medical advice to you. Best health to you!
Def agree @RapAdmin. It’s probably why she’s quite risk averse when it comes to Rapa.
I’m sure the Rapalog will be safe in humans though Might cost a bit more
No, she is unchanged. If you watch the video, they often ask her about rapamycin, and she always says that her molecule does exactly the same thing. She has always been cautious about taking rapamycin before it has been proven effective in humans.
Joan is very articulate. She explains things very well. However a couple of things jump out. She says her rapalog is slightly more absorbable than rapmycin. Otherwise pretty much 6 of one, half dozen of the other. Then she says we really don’t know much about rapamycin, so wait until my drug is tested and ready, to be safe. While much is unknown about rapamycin, there is a good amount od data and research, more every day. tying it in with supplements that make wild claims is a little bit disingenuous. Dr Warren in Utah has been taking rapamycin for 5 years. He prescribed it for me. There are others like him. And many on this forum and others. More every day. I’have no doubt that Joan is aware of this. No or small side affects sold me. I haven’t taken it very long but so far no side affects. I turned 75 recently. The ideal age, according to Joan, to start rapamycin. Sounds good to me!
But - its not a bad idea to search on the site to see the existing discussions on any given topic (and add your question there, if the discussion is focused on your topic of interest), just to reduce the number of times we get the same question over and over.
Hello,
As I live in Europe, it’s difficult to obtain rapamycin. I’ve talked to several doctors; they only prescribe it for official indications (kidney transplantation and certain cancers). In the meantime, I’ve discovered another molecule that’s also very interesting: spermidine, which strongly promotes autophagy. Spermidine can be found in wheat germ,cashew nut and Cheddar cheese. That’s what I consume while waiting to find a way to obtain rapamycin.
Michel
Help, please!
I’ve started RAPA. My functional med MD rx’d me 2 mg weekly for senescent cell treatment, along with daily NAD+ injections and once-a-month Qualia.
Everything I’ve read here on this site points to a 6 mg dose weekly.
My doc asked me for the research pointing to the 6 mg does. Can anyone point me to “solid evidence” I can send him showing 6 mg dose?
Might cost a bit more 
