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#41

PEARL study results have not been revealed yet (to the best of my knowledge): PEARL Study Results (progress)

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#42

Here is the Mannick information: mTOR inhibition improves immune function in the elderly - PubMed

The full paper: https://health.uconn.edu/aging/wp-content/uploads/sites/6/2016/04/mTOR-inhibition-improves-immune-function-in-the-elderly.pdf

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Breaking: 15% Healthy Lifespan improvement via Rapamycin seen in Marmosets
#43

A post was split to a new topic: PVC’s (premature ventricular contractions or extra heart beats) and Rapamycin?

#44

Interesting - is this common practice and safe, besides possible interactions w other drugs?

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#45

Doctors don’t generally recommend it, read more here: Improve Bioavailability of Rapamycin (2)

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#46

It becomes a problem if you have other medications that interact with grapefruit. Otherwise it’s fine IMHO.

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#47

Some medications that can interact with grapefruit include:

  • Cholesterol drugs: Atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor)

  • High blood pressure drugs: Felodipine (Plendil), nifedipine (Procardia), and nisoldipine (Sular)

  • Heart arrhythmia drugs: Amiodarone (Cordarone) and disopyramide (Norpace)

  • Anti-anxiety drugs: Buspirone

  • Blood thinners: Eliquis (apixaban), Plavix (clopidogrel), and Xarelto (rivaroxaban)

  • Antidepressants: Sertraline (Zoloft)

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#48

Interesting the vascular effect of rapamycin…
A Japanese team (Ozeki et al. 2025) published a study that may help on this matter. The results were good considering that the vascular anomalies were “intractable”: “Sirolimus treatment for intractable vascular anomalies (SIVA): An open‐label, single‐arm, multicenter, prospective trial”

(…) “Patients received sirolimus tablets or granules (Rapalimus Tablet or Granules, Nobelpharma Co., Ltd., Tokyo, Japan) orally once a day, either after meals or on an empty stomach. The initial dose of oral sirolimus tablets in patients weighing ≥30 kg was 2 mg/day. The starting dose of sirolimus granules in patients ≥30 kg was 0.7 g, equivalent to 1.4 mg of sirolimus, and the initial dose in patients <30 kg was calculated based on the patient’s age and weight (Table [1]. Dose adjustments were made according to sirolimus trough concentrations measured in the second week, to achieve a target concentration of 5–15 ng/mL.”

(I have doubts about rapa intake with or without food)

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#49

Hi There

What are your thoughts on Bryan Johnson who recently stopped taking Rapamycin claiming tests prove it will in fact accelerate ageing?

Thoughts?

Thanks

Dino

#50

See this long thread: Bryan Johnson stops rapamycin

and this related thread on one of the key research papers Bryan used to justify his ceasing rapamycin: The Effect of longevity interventions on epigenetic clocks (BioRxiv)

You may also find this thread of interest: Chris Masterjohn: Rapamycin, "The Worst Longevity Idea Ever Conceived"

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