AX3 is not approved for human consumption??
Synthetic astaxanthin is not currently approved for human consumption in most countries, including the United States and the European Union. This is because it has not been through the rigorous safety and efficacy testing required for food and drug approvals.
Only naturally-sourced astaxanthin, primarily extracted from microalgae like Haematococcus pluvialis, is generally recognized as safe (GRAS) for human consumption by regulatory bodies like the US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA).
Here’s a breakdown of the current status of synthetic astaxanthin:
- Food: Not approved for use in food or food supplements in most countries, including the US and the EU.
- Animal feed: Approved for use in animal feed in some countries, including the US.
- Cosmetics: Approved for use in some cosmetic products in certain countries.
There are some concerns about the safety of synthetic astaxanthin for human consumption. These concerns include:
- Limited safety data: There is not enough safety data on synthetic astaxanthin to be sure that it is safe for humans to consume.
- Potential for impurities: Synthetic astaxanthin may contain impurities that could be harmful to humans.
- Unknown bioavailability: It is not known how well synthetic astaxanthin is absorbed by the human body.
No, thats not correct - there is lots of information on the DSM product approved for supplement use in the US in this thread. Astaxanthin, Natural vs. Synthetic - Your Thoughts?
1 Like
It looks like ChatGPT to me.
This is not true. DSM has self-affirmed GRAS for their synthetic asta via the FDA. This is a laughable process, but the evidence is not zero and includes both human and nonhuman primate oral supplementation studies. It’s absolutely approved in the same sense as any other dietary supplement with this status, both as a food additive and a supplement.
3 Likes
Fair enough! Food safety is a tortured area. Food production methods and the food itself are two separate issues.
Here’s the general outline for US FDA GRAS self-certification. “GRAS self-affirmation allows a company to determine, based on scientific evidence, that a substance is safe for its intended use in food and does not require pre-market approval from the U.S. Food and Drug Administration.”
Thanks for posting. Translation from mice to humans is imperfect but the Asta dose used for mice would translate to grams for humans if I converted correctly. My Astaxanthan supplement is 4 mg which I’ve been using on and off for years. Makes me wonder what ITP’s criteria was for choosing such a high dose. It would also help if the authors, knowing this is a supplement, would put into context of human dose equivalent to avoid so much confusion.
Do we have an updated file with all the tested drugs (as of today), including Asta and Mec?
Sorry, my question wasn’t clear: I meant with the results. The Apollo Health Ventures file isn’t up-to-date with the Asta and Mec results (and fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate).
The results are given in the NIA page RA linked.
The NIA page doesn’t have the results. And it’s not up-to-date, for instance, it says that “Astaxanthin” is still “In Progress”.
I’m talking about something like this but up-to-date: a clear spreadsheet with all interventions (inc. details of dose and age) and detailed results by gender, median increase, max increase, p-value, etc.
1 Like
No - I don’t think anyone has done it yet. Please post if you run across something like this.
Whats their prices? Have you gotn quotes?
Actually, Apollo Ventures did it! I didn’t notice it, but they’ve just added “Update 12.2023” in the title, updated the image to show Asta, Mec, Fisetin, and other recently tested drugs, and updated the text accordingly (e.g., “The recent ITP Paper published a fairly famous failure: The compound Fisetin did not show any lifespan benefit using the established treatment protocol based in cohorts commencing with treatment in 2018 and 2019.”).
6 Likes
Well I can’t find a source for 17 a-estrodiol so where would one find 16-Hydroxy estriol?
Would like to hear Miller’s rationale for the dose of astaxanthin used as it so out of line (extremely high) with supplemental and dietary sources which are typically < 10 mg.
Another example in which paper authors fail to translate doses used into human equivalent and typical human consumption to help put study results in context.
2 Likes
They asked the funders of the study, multiple researchers etc which dosage would be best to test.
I just wanted to drop an anecdote, and hopefully this is an okay place to do it. I came to this forum looking for ways to improve a chronic health condition I have that causes inflammation to my joints, lungs, lymph nodes, and gives me heart palpitations. I’m not even sure what the specific condition is. But I tried rapamycin and it worsened the inflammation quite significantly and caused more pain even at smaller doses (and because of the half life would last a long time). Specifically Biocon Sirolimus.
However, I have also tried meclizine now and it seems to actually improve my condition a quite notable amount (which is very rare to see based on the success rate of other things I’ve tried), it can decrease the swelling of my joints a decent amount, and it doesn’t cause me the same problems rapamycin did. I’m not sure if this is because of mtor effects, or something else, but looking around there was a bit of research showing meclizine decreased osteoclast activity, and osteoclast generation. There may be more to its (potential) positive effects aside from just affecting mtor.
In terms of side effects, I seem fine, even up to 50mg twice a day (as long as I avoid the kind with lactose in it), just a bit more dry eyes. I don’t know if it is good to necessarily take this much though.
4 Likes
Hi - and welcome to the forums. Thanks for posting your experience. I find it really strange that you had good results with meclizine and negative results with rapamycin…
The entire reason we cover meclizine here is because of this new research - also covered here: Meclizine / Dramamine II, Approx 15% Lifespan Increase, Another mTORC1 Inhibitor
That says meclizine does much the same thing as rapamycin, at least when it comes to mTOR.
Glad to hear you’re doing better with meclizine, but I have no idea why you’ve had the experiences you have; rapamycin is supposed to be (and in my experience is) a great inflammation reducer.
4 Likes