Dr Brad Stanfield has a very different take on that same study:
Diving into the details of the study, however, reveals a bizarre method, and the results should NOT be over-interpreted
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I am currently taking B3, but not NR or NMN, but I share Brad Stanfields scepticism about the cancer study linking NR to cancer.
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As Peter Attia mentioned, they were given 100x the usual dose of NR and literally had aggressive cancer cells injected into their bodies.
I would contrast this with the ITP studies, which, while they showed no effect on lifespan, they also showed no effect on lifespan. In a more natural situation, the mice did not develop increase incidence of cancer.
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If you look at the raw data you can see that NR lowered median lifespan (albeit not significantly):
As a weekly rapamycin user, i got skin rash every time i took NR/NMN on the first few days of 6mg rapamycin dosing.
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The ITP data is perhaps more negative about NR than the Cancer study. In any event with the recent research pointing at gene length determining what genes stop working we are pretty well there now on what causes aging.
Peter Attia’s professional background is surgery - general surgery, later oncologic surgery. At least, that is what wikipedia says.
I wonder how many other members of this forum who report skin rashes after taking rapamycin are also taking NR or NMN?
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It’s true that I take NMN and have skin rashes. But I think RapAdmin doesn’t take NMN or NR and got rashes as well.
My rashes can be treated with isoconazole .
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I think Dr Attia and Dr Stanfield actually have similar opinions and I agree with both. The cancer risk is questionable and minimal. The benefit is questionable if any. The benefit does not significantly outweigh the risk so why take it?
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It’s great for healthspan and energy levels. Instead of feeling tired every single day, I am alert, active and energetic. What good is a long life if you are always fatigued? You are sleeping through life!
After reading a prior post of yours, I tried NMN, but didn’t notice any effect.
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Unfortunately, it doesn’t work for everyone. I get too little sleep, so I think that’s why I feel the effect.
Also most of the NMN being sold on Amazon is fake. Too many people end up buying a supplement with no NMN in it.
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I would not say most of the NMN on Amazon is fake. Some of it clearly has no NMN. However, being within 10% of the published amount does not to me seem to be fake.
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True - only 64% of the sampled brands had under the detection or reporting limit, and 14% had no NMN in them I recall.
Report on NMN supplement products: (this study only looked at the % NMN, not for any contaminants)
(and this doesn’t even touch the broader issue of whether NMN is at all effective in increasing healthspan or lifespan - as there is no good human data on that yet, and many opposing views).
Out of 22 NMN Brands tested:
- 14% had at the level, or above, level of claimed NMN
- 23% had between 89 and 99% of the claimed level of NMN
- 64% had NMN had under the method detection or reporting limit, or under 1% of claimed NMN
- 14% had no NMN
Summary:
DETAILS:
Quantitative Analysis of 22 NMN Brands - Lab Analysis / Quality Analysis
Video: 22 NMN Brands Independently Tested | SHOCKINGLY POOR RESULTS FOR MANY BRANDS
Got mine at donotage
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DoNotAge is the real stuff. I am sorry it has no effect for you. My best friend had to give up NMN because it gave him too much energy and he couldn’t sleep!
I would say 64% with no or undetectable NMN would be considered ‘most’.
If it has no effect on you, I guess that could mean that you get enough sleep and are a very healthy individual!
Yes, this study was debunked by several scientists as being bad science.
The ITP tested NR on mice and it did not affect lifespan in any way. Mice die of cancer most of the time, so if it enhanced cancer, the ITP would have found it.
Stanfield had a video about why this study was not very good .
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The 14 marked with a star are the same distributor. The study was in 2021 and i dont think those are still on amazon. Hence i think the problem is now smaller.
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See my post above, NR reduced median lifespan.
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