Sorry Steve - I thought we were talking about NMN?
Got my wires crossed, yes to NMN as providing a potential Pace improvement.
But I think the senolytic program may have had more influence.
The reason I think that is 4 other people followed a 7 month protocol on it (no NMN or NR) and every one had an improvement in their TruDiagnostic scores, including Pace.
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It’s wishful thinking to expect such low doses of apigenin to have significant effects on NAD+ levels. It’s oral bioavailability is far too low for that. I think it’s misleading to promote it as a supplement to increase NAD+ levels IMO.
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In part yes, but it’s mainly a matter of bioavailability. Apigenin is heavily metabolized in the intestines and by the liver in rodents and humans. In mice, this results in very low bioavailability, in humans it’s even worse, since they metabolize it even more strongly.
IIRC, the main study that found that apigenin inhibited CD38 in vivo and created interest in apigenin as a means to inhibit CD38 was a mouse study that use very high doses given intraperitoneally. The intraperitoneal route bypasses the intestines and liver. The mice would need a lot higher oral doses to get the same amount in your blood as they got with the intraperitoneal injection.
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There is a case study about a patient drinking parsley juice daily. The levels of sirolimus increased dramatically. Was it an effect of the apigenin in the parsley? Or something else in the parsley?
And starting at 1.25.50 this video digs deep into the NMN and NR question. Including strongly advising against intrevenous NAD at 1,52,24
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It’s hard to say. Apigenin has some CYP3A4 inhibitory activity so it could be the apigenin. However it could also be something else in the parsley, I’m not sure. Characterization of the CYP3A4 Enzyme Inhibition Potential of Selected Flavonoids - PubMed
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I always wonder why a poorly studied compound like apigenin is promoted and consumed as a NAD+ booster when there compounds like NMN and NR that have significantly more human studies showing that these 2 do increase NAD+ and the doses that work.
Reinventing the wheel is not my thing. So I alternate between NR and NMN, generally 3 month cycles.
And I’ve seen my telomeres increase consistently via TrueDiagnostic testing with 5 tests over 4 years. Should have my TD test result #6 in a few weeks.
And the whole hype around NAD+ IV’s that don’t work.
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