NAD+: nicotinamide mononucleotide or nicotinamide riboside?

I am confused as to which is more effective. And further, it appears there is more than one form of nicotinamide riboside (NR) to consider (NR chloride and NR Hydrogen malate…I think?).

In yor opinions, which is the most efficacious in raising NAD+? Or are there other alternatives as good or better?

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Calculate the cost of 1000 of NMN vs. the cost of 600 niacin IR. Makes it even worse.

Then later he figured out that having high NAD might make you age faster. Who knows whether this is true. If it is then I’m it trouble because I’ve had a full shit ton of Niacin IR.

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Just found this. Need to watch later.

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Bryan Johnson trialed both and saw good effects with either

He used Jinfinti that is a simple at home test to test before and after values.

(probably his experiment and the discussion of the test should be on his protocol webpage, def on his twitter and I think also discussed on this forum if you search)

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Actually age faster or more that it might interfere with methylation based tests?

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New study out of Japan on NR’s effect on Werner Syndrome “a rare genetic disorder that speeds up the aging process and brings life-threatening complications.”:

https://scitechdaily.com/vitamin-b3-pill-rewinds-premature-aging-in-groundbreaking-human-trial/

The results were striking: NR boosted heart and blood-vessel health, shrank stubborn skin ulcers, and slowed the loss of kidney function. For a disease with virtually no treatment options, these improvements hint at real hope.

People with Werner syndrome start showing signs of old age in their twenties. Gray hair, balding, cataracts, diabetes, and other illnesses that usually emerge late in life arrive decades early. Painful skin ulcers often resist healing and can lead to amputations, while heart disease and cancer shorten life expectancy. In Japan, about nine out of every million people are affected, and effective therapies have been frustratingly absent.

Perhaps a similar result could be had using plain niacin, nicotinamide, NMN, and others.

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I have used both NMN and NR over the past couple of years and have posted my positive telomere results.

I ran out about 6 months ago and have been thinking that my energy levels have dropped a bit. I ordered some NMN and NR in bulk and am starting back with 500mg of NR daily for a month then 500mg NMN for a month. I’ll be alternating back and forth for a year and see how that goes :slight_smile:

July the FDA will rule on the legal status of NMN, whether it can be sold as a dietary supplement or only as a drug,

The “problem” is that if they deem NMN to be a drug, it has not gone through the drug approval process so it may be years before it could be “prescribed”. Even though it’s been sold as a dietary supplement for over 10 years and appears to have a good safety record.

Theoretically it could still be sold as a “research chemical”, similar to how peptides are sold.

NR has it own set of availability issues but again it could be available as a research chemical.

Fortunately I know a guy :slight_smile:

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