I am confused as to which is more effective. And further, it appears there is more than one form of nicotinamide riboside (NR) to consider (NR chloride and NR Hydrogen malate…I think?).
In yor opinions, which is the most efficacious in raising NAD+? Or are there other alternatives as good or better?
Calculate the cost of 1000 of NMN vs. the cost of 600 niacin IR. Makes it even worse.
Then later he figured out that having high NAD might make you age faster. Who knows whether this is true. If it is then I’m it trouble because I’ve had a full shit ton of Niacin IR.
Just found this. Need to watch later.
Bryan Johnson trialed both and saw good effects with either
He used Jinfinti that is a simple at home test to test before and after values.
(probably his experiment and the discussion of the test should be on his protocol webpage, def on his twitter and I think also discussed on this forum if you search)
Actually age faster or more that it might interfere with methylation based tests?
New study out of Japan on NR’s effect on Werner Syndrome “a rare genetic disorder that speeds up the aging process and brings life-threatening complications.”:
https://scitechdaily.com/vitamin-b3-pill-rewinds-premature-aging-in-groundbreaking-human-trial/
The results were striking: NR boosted heart and blood-vessel health, shrank stubborn skin ulcers, and slowed the loss of kidney function. For a disease with virtually no treatment options, these improvements hint at real hope.
People with Werner syndrome start showing signs of old age in their twenties. Gray hair, balding, cataracts, diabetes, and other illnesses that usually emerge late in life arrive decades early. Painful skin ulcers often resist healing and can lead to amputations, while heart disease and cancer shorten life expectancy. In Japan, about nine out of every million people are affected, and effective therapies have been frustratingly absent.
Perhaps a similar result could be had using plain niacin, nicotinamide, NMN, and others.
I have used both NMN and NR over the past couple of years and have posted my positive telomere results.
I ran out about 6 months ago and have been thinking that my energy levels have dropped a bit. I ordered some NMN and NR in bulk and am starting back with 500mg of NR daily for a month then 500mg NMN for a month. I’ll be alternating back and forth for a year and see how that goes 
July the FDA will rule on the legal status of NMN, whether it can be sold as a dietary supplement or only as a drug,
The “problem” is that if they deem NMN to be a drug, it has not gone through the drug approval process so it may be years before it could be “prescribed”. Even though it’s been sold as a dietary supplement for over 10 years and appears to have a good safety record.
Theoretically it could still be sold as a “research chemical”, similar to how peptides are sold.
NR has it own set of availability issues but again it could be available as a research chemical.
Fortunately I know a guy
Scientists from the University of Oslo (UiO), Akershus University Hospital (Ahus), and international partners have released a new expert opinion in Nature Aging . The article brings together more than 25 researchers from around the world, including clinicians and internationally recognized leaders in the biology of aging and metabolism, particularly in the study of nicotinamide adenine dinucleotide (NAD⁺).
This study reviews years of research and clinical trials where scientists have tested ways to increase NAD⁺ levels, often by giving patients special vitamin-like compounds such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN).
Early results are encouraging, with some trials reporting improvements in memory, movement, and metabolism. The researchers highlight that larger and longer-term clinician studies are needed to validate its clinical efficacies against different conditions.
Paper:
More information: Jianying Zhang et al, Emerging strategies, applications and challenges of targeting NAD+ in the clinic, Nature Aging (2025). DOI: 10.1038/s43587-025-00947-6
Steve what’s happening here?
Decision has been delayed until Sept 30, we’ll see.
Sept 30 the FDA decided that NMN is a dietary supplement.
Good news for many of us.
NMN and NR increased our telomere length consistently over 5 tests in 4 years. Most will say that is irrelevant to aging but it may be my interest in Telo length stems from how that happens, and it requires the enzyme telomerase to do that.
Telomerase has other health related benefits so I consider longer telomeres indicate a healthy telomerase production system.
Seems mixed. There will be less incentives to do more human clinical trials and even studies on other animals now.
This your N=1 data or from a study?
Our personal results using Trudiagnostic tests N=2
There have been about 18 human clinical studies specifically on NMN supplements, with additional preclinical animal and in vitro studies overall.
Even a dietary supplement, if marketed correctly, can support the cost of studies.
There are over 35 clinical studies published on Nicotinamide Riboside (NR) as of 2025.
Most are small scale and short duration.
Many people use these 2 compounds, we alternate, a couple months with NR and a couple months with NMN
do the studies on NR and NMN indicate telomere lengthening.pdf (159.5 KB)
Cool that you have so many measurements with them - how did your other metrics and Pace change with NMN?
Do the epigenetically predicted telomere lengths correlate well with actual measured ones? Believe epigenetically predicted like HbA1c, etc were quite bad?
Cool that you have so many measurements with them - how did your other metrics and Pace change with
Ran both NMN and NR supplementation for several months. No subjective response whatsoever. However, I still believe NAD+ optimization has merit.
My current protocol (both before sleep):
Niacin 50mg - NAD+ precursor, promotes prostaglandin synthesis (sleep-supportive), favorable lipid effects. Dose well below the threshold associated with 4PY accumulation and cardiovascular risk in recent literature.
Apigenin 50mg (on top to chamomile tea) - CD38 inhibitor, reduces NAD+ degradation rate.
Targeting both NAD+ synthesis (precursor) and degradation (CD38 inhibition) simultaneously. Add melatonine to this stack - and you have never slept better. Whether it’s the prostaglandin support from niacin, the anxiolytic effects of apigenin, or actual NAD+ optimization…
My Pace decreased significantly 1.2 to 0.89 BUT I don’t attribute that progress entirely to GlyNAC. I was also doing some intense clearing of senescent cells for a couple years before I started GlyNAC as that is what go me doing the Tru tests. Then about 2 years in I added GlyNAC.
Also the last test I had done was also 1 year into Rapamycin
I doubt the GlyNAC had that much effect on my Pace but who knows, when one is throwing the kitchen sink at increasing health span.
Tryptophan is an important actor in the NAD de novo pathway.
About 2 weeks ago we added 1000mg just before bed, not specifically for sleep as we are both excellent sleepers, just did not want the Trypto to make us sleepy during the day.
Tryptophan is an important actor in NAD production.pdf (172.9 KB)
Thank you, @Steve_Combi, was unaware about this pathway. Seems not so potent acc. to source below, but can be taken into account
that doesn’t make much sense to me, niacin is not NAD+? is there something missing?
In conclusion, accounting for pathway losses, 1 g of tryptophan yields about 10-12 mg of NAD+ via the de novo pathway in humans, reflecting the complex regulation and metabolic demands in the body.
I use tryptophan as a “back up” to ensure that the NAD+ levels are supported through various pathways. One of the reason I switch back and forth from NR and NMN.
Estimate NAD+ yield from 1 g tryptophan accounting.pdf (157.3 KB)