Using a little AI app to gather some info on this peptide is why I’m wondering if it could be the ideal companion for Rapamycin. Anyone have any experience with this one?
MOTS-c is a mitochondrial-derived peptide that has shown promising potential in metabolic regulation, anti-aging, and disease prevention. However, there is limited clinical data on its effective dosing in humans. Most of the available information comes from animal studies and preliminary human research.
MOTS-c offers a range of potential benefits, including metabolic regulation, anti-obesity effects, enhanced insulin sensitivity, exercise mimetic effects, longevity and anti-aging benefits, protection against metabolic syndrome, and enhancement of the cellular stress response. These benefits make MOTS-c a promising therapeutic agent for various metabolic and age-related conditions.
As far as I understood mTorC2 is only influenced at higher blood levels of rapamycin. If that is correct that would simplify the summary of mechanisms you provide.
I wonder if you are looking at this combination to increase positive effect or more to lower adverse effect(s).
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People here are using it, but I’ve yet to see much in the way of clinical evidence for efficacy, just anecdotes. The entire peptide arena seems more like the cosmetics market, lots of noise and anecdotes by “influencers”, but very little good data, animal or human. If you find any good data, please share.
Yes, most of the data is from Russia. There is unlikely any good data anytime soon as drug companies have almost zero incentive to do studies on peptides.
It would be nice if governments provided more money for worthy scientific studies of the efficacy of supplements and other alternative medicines.
Anecdotally, I am quite happy with my first foray into peptides. Semax seems very effective, at least for older minds, for improving brain fog, etc.
There is quite a large amount of “anecdotal” evidence for the effectiveness of peptides.
At least, they offer a ray of hope for those suffering from certain medical conditions.
I will continue to explore and be one of the “canaries in the coal mine”.
Our body makes 7,000 known peptides, we are a peptide factory and we can’t exist without them.
MOTS-c is not an unknown, the natural production of MOTS-c in our body and it’s actions are reasonably well understood. Adding more through subQ injection at the right time, just before an exercise session for example, may be the right time.
One thing I wanted to know is if our production or MOTS-c decreases as we age. So I asked my new AI friend and it confirmed that it does. Like many things our body is good at when we are young, this one also becomes impaired.
One way MOTS-c is produced in our body in response to exercise. It is produced in various sites, including skeletal muscle, liver, and adipose tissue. Due to it’s short 3 hour half life, the small amount produced by our body doesn’t last very long.
“There are thousands of known peptides, with new ones continually being discovered and synthesized. The exact number is challenging to determine due to the vast and growing nature of peptide research.”
When it is claimed that there is no evidence for the efficacy of using peptides let us remember that several peptides have been extensively studied and approved by the FDA for treatment.
"Insulin is a peptide hormone, composed of two polypeptide chains:
A chain: 21 amino acids
B chain: 30 amino acids"
“Several peptides have been approved by the FDA for therapeutic use. These include insulin for diabetes management, oxytocin for inducing labor, vasopressin for treating diabetes insipidus, and glucagon for severe hypoglycemia. Other approved peptides include somatostatin and its analogs for various endocrine disorders, gonadotropin-releasing hormone (GnRH) and its analogs for reproductive health issues, and calcitonin for osteoporosis. Synthetic peptides like liraglutide and exenatide are used for type 2 diabetes and obesity. Additionally, various antimicrobial peptides, such as daptomycin and colistin, have been approved for treating bacterial infections. This list is not exhaustive, as new peptide-based drugs continue to be developed and approved.”
I think the use of peptides is the most exciting thing I have come across since discovering rapamycin.
I agree 100% it’s been the thing that has made the most difference in my progress since I started the longevity journey in 2018.
The biggest problem I have is deciding which one to try next LoL!
Starting MOTS-c July 28, a bit earlier than I was planning on as I’ll be doing my 9 month Tru test in Sept but this addition should not make that big a difference in 1 month. So we’ll see again (another 9 month wait) in May of '25 how that goes but I’m sure I’ll confound that with additional peptides LoL!
It’s hard to be patient when the light at the end of the tunnel is fast approaching.
Since MOTS-c appears to inhibit the “negative” potential of higher and extended use doses of Rap, I’m going to try that method for a bit.
Right now we take 6mg with GFJ and EVOO every 2 weeks. No discernible issues and no discernible benefits.
Was thinking of a 6mg week, followed by a 3mg week to maintain a higher “low” level of rap in the system. Using MOTS-c to keep Raps indirect effect on MTORC2 at bay.
I’m running a cycle now. 5 mg MWF for a month twice a year. Slight irritation at the injection site, which tells me that the MOTS-c is good and hasn’t degraded. I follow Dr. Seed’s protocols for all my experiments. He recommends much lower doses than others, usually 100-300 mcg for most peptides. Those pushing higher dosages seem to have a financial motive.
Me too. I also use Semax when I go diving into prime numbers.
Yes, the number of self-proclaimed experts is increasing exponentially, especially on YouTube. However, there is an abundance of good, solid research on peptides such as MOTS-c, including dozens of papers on PubMed. On the other hand, there is little or no research in the West on bioregulators, which I am skeptical of. Why have Western scientists ignored biorergulators when they have, to good effect, put peptides under the microscope?
I was referring to Rapamycin. I recognise there is something to be looked at with peptides, but I am currently in the middle of sorting out renal biomarker issues and don’t want to add peptides to that.
I can trace the effect of alcohol on my kidneys by watching my GFR. If I have 2-3 drinks maybe twice a week or so, my GFR plummets. When I stop, it goes up again.
I don’t have any problem with tomatoes, but citric juices irritate the bladder. To maintain the blood’s carbon dioxide level, a measure of acidity, I take 9.75 grams of sodium bicarbonate daily. At first, the neph department discouraged my use of baking soda, but they eventually came around when the results were so positive. I think that some MDs don’t keep up with the literature.
I think you are probably right that alcohol has an impact on kidney biomarkers. However, I was eating stupid amounts of tomatoes so have stopped.
In the past I had the kidney biomarkers in a really good state, but they have been a bit iffy more recently. Probably in part because of really heavy alcohol consumption, but also tomatoes and chololate. Hence I am working on changing aspects of my diet to bring them back into line. The citrate supplementation can be an issue as well on high levels because of the cations.
Request.
Can anybody please provide an original leaflet in PDF format for MOTS-c if it is included in the package in this forum or per my mail. My only Russian knowledge is from a course over 50 years ago. So for me and presumably for many others on the forum a translation in English would be welcome as well.
Similarly I would appreciate to see leaflets for other peptides like epithalon etc. @RapAdmin Could this be something for a separate topic?
Thanks.
Started my MOTS-c experiment yesterday. Took a shot about 10 minutes before my workout. It’s a low dose (100mcg) to evaluate any noticeable downside. No apparent issues. It is a very light workout as I’m slowly getting back into this aspect of doing better I’ve had injuries related to lifting “heavy” 40-30 years ago and just trying to be more fit, not striving to out lift anyone
Will be doing this just before every workout (4 per week) usually around 5:00pm, plus on off days, in the morning.
Will up the dose over the next 6 weeks to my target of 250mcg per day.
If there are no issues, I’ll then change my Rap schedule from every 2 weeks to once a week. Week 1 and 3 at 6mg week 2 and 4 at 3mg. Any month with 5 Mondays I’ll take the extra Monday off. That should be twice a year.
I’ve had injuries related to lifting “heavy” 40-30 years ago and just trying to be more fit, not striving to out lift anyone