@DeStrider That is a good question! I am only learning about now but am composing a list of questions for my doc!
And thank you @matthost
@desertshores that is quite a list !
@Joseph_Lavelle Someone mentioned sglt2 to me yesterday. I haven’t heard about this before and need to ask my doc. Thx
Group reply so i don’t clog up the thread 
Is there a reason you take metformin AND berberine (well, I know there is a reason, but am curious as to what it is
I was under the impression is they are very similar… just learning incase it’s ever something I want to consider
Is it the sugar, i assume? It’s not as good, but I’ve been having chocolate with allulose which is good enough to satisfy my cravings… but not so good that i eat a million of them.
I take berberine instead of increasing my metformin dose. Berberine has no subjective side effects for me. Too high of a dose of metformin caused me to have some acid reflux. I have tried various doses over the years and 500 mg/day is all I can tolerate.
Also: “Some studies suggest that taking berberine with exercise can help build muscle more than exercise alone.”
Interesting read, I should of linked this study to the doctor who accused me of being a bodybuilder abusing diabetic drugs 
You can read up on SLGT2 inhibitors / Canagliflozin here: Canagliflozin - Another Top Anti-aging Drug
But - it didn’t have the lifespan benefits in females (mice) in the ITP studies.