Metformin dose and schedule

For those taking Metformin what dose and dosing schedule do you use. I am also interested in a schedule that works with strength training. Thx

Hi, you may want to review this earlier thread on rapamycin and metformin: Rapamycin + Metformin

To minimize the negative effect of metformin on exercise benefits, I imagine you’d want to pulse dose the metformin. The half-life of regular metformin (not the slow release version) is 6.5 hours.

Nir Barzilai is a proponent of metformin:

I hope others post here on what schedule works best for them…


I take 500 mg Metformin after my evening meal. Been taking Met long before I heard of Rapa. Glucose was in the 124 range, now stays around 99 to 103 in blood test over the past 12 years. Been taking 6 mg Rapa for 4 months. 79 years old and no noticeable effects. I do exercise but not strength training.

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Well, what nobody talks much about is the degree to which Metformin blunts hypertrophy. I don’t remember exactly but it’s a miniscule amount, IE: if you are competing in the open class of the Mr Olympia this year, you might not want to use it.
As previously mentioned, it has a half life of about six hours. I work out in the mornings around 10 AM so I take 1000 mg of Metformin with my evening meal (6PM). I’m 66 and have as much or more muscle as I have ever had.
Make sure your free testosterone is in the high end of the range (men), consume 1 gram of high quality protein per lb of body weight (remember, older people need more protein as our bodies don’t synthesize protein as efficiently as when we were young), and lift properly and you’ll be fine, Metformin or no Metformin.


It’s the inhibition of adaptation to endurance (VO2 max) training not muscle mass that is most significant.

Falls, broken hips are, I believe, the second or third cause of death in persons over 65. Strength training not only helps maintain bone density but muscle strength helps avoid a fall and muscle mass is critical when, after suffering a broken hip, one is bedridden for a long period of time as the muscles atrophy quickly. Peter Attia has addressed this several times in his podcasts citing studies.


Think you created a straw man there, I’m not disputing the benefits of strength training.


Again, the question would be how significant? Statistically, or enough to affect real-world results? It would be a shame to miss out on all the possible benefits of metformin if the VO2max effect could (for instance) be overcome with an extra few min of cardio per week. Just speculating here, not asserting that this is the case.


IMO: In order to increase healthspan I am no longer going to take metformin. Metformin has served me well for ~30 years. I took it because of the articles that claimed lifespan improvement in those taking metformin for type II diabetes.

I have never been type II and even though my fasting glucose has increased with age, I have recently tried to go without metformin. I use Empagliflozin instead and it seems to work well.

The main reason I am stopping metformin is that I think I have reached the age that metformin may not be beneficial for me. Most of the benefits of metformin can be achieved by diet, TRF, supplements, exercise, etc.

Now that I am 81, I do not want to take anything that may inhibit keeping my muscle mass.
Though I have not really noticed any detrimental effects on my strength training, metformin is known to inhibit muscle mass gain through strength training. IMO this inhibition is small, but at my age, I want no inhibition to maintaining or gaining muscle mass.

If I had to do it over again I would do the same thing. I think metformin is a good choice for younger people. As I have posted before, it has served me well.
To be blunt: This is mainly by association, not causation. I am alive and well and everyone I know who didn’t take metformin has all died before me.