Melatonin megadoses?

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Melatonin suppresses glycolysis and coordinately disrupts DNA repair via targeting the YAP1-NAMPT signaling in breast cancer 2025

Highlights

• Melatonin inhibits glycolysis and aggressiveness in TNBC.
• Melatonin downregulates YAP-NAMPT expression.
• Melatonin suppresses the crosstalk between glycolysis and DNA repair signaling.
• Combined treatment with melatonin and Olaparib enhanced therapeutic effectiveness.