Melatonin megadoses?

#590

Melatonin suppresses glycolysis and coordinately disrupts DNA repair via targeting the YAP1-NAMPT signaling in breast cancer 2025

Highlights

  • Melatonin inhibits glycolysis and aggressiveness in TNBC.
  • Melatonin downregulates YAP-NAMPT expression.
  • Melatonin suppresses the crosstalk between glycolysis and DNA repair signaling.
  • Combined treatment with melatonin and Olaparib enhanced therapeutic effectiveness.
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#591

The one paper I’ve seen, across years of seeing positive melatonin trials, that made my heart skip a beat as a heavy melatonin user

But I’m balls deep, been taking high dose melatonin for years and am a firm believer in it. It would take me disruption and time to get off it. This would be like being married to and believing in a spouse and hearing a unfaithful rumor

Fortunately, again, it’s the one negative paper I’ve ever seen on the substance, and you immediately drew on another paper right after it pointing to heart health High-Dose Melatonin Reverses Artery Hardening by "Waking Up" the SIRT6 Longevity Gene - #8 by RapAdmin

so I will pretend like I didn’t see it

#592

Yeah, so many of these trials on these meds dont take into account the problems of the people needing them in the first place. Like possibly statins have ‘no affect on lifespan’, but is it people with dyslipidemia taking statins to get where normal people already are and not folks in the longevity scene using it to get to low levels. The people taking melatonin may have needed it due to a underlying insomnia that was wrecking their health

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