After my PT told me he noticed some strength gains, I said, “Too bad the brain part didn’t work!”
He disagreed. He said he thinks my protocol is helping my brain (who knows what!). He notices I follow all the medical stuff we discuss much better.
I told him I notice that too, but I think it’s just because I now immerse myself in my Claude health project, so I think exposure is what is helping me.
My memory is significantly better than it used to be, including in my youth, but that was happening since starting all this stuff over the last year or two, prior to maraviroc. If it’s helping me, I can’t pinpoint to anything, but it does continue to get better. So I’ll say yes to strength and I doubt my brain.
I see we have a few Maraviroc threads so I’ll make an audible and post this here… move if helpful… and sorry if it’s a repeat…
Claude found a couple papers so I had him summarize them for you:
Two maraviroc papers worth having in this thread: one new mouse study, one older human pilot.
MOUSE: maraviroc and inflammation-driven Alzheimer’s damage
Liu et al., Translational Psychiatry, July 2026
5xFAD mice (an amyloid model), 3 months old, so early stage.
Three days of LPS (a bacterial toxin) to provoke inflammation, then three days of maraviroc, 20 mg/kg, injected.
After LPS, maraviroc improved working memory, place memory and object memory, cut plaque load, and lowered IL-1β and TNF-α in the hippocampus.
The catch: in 5xFAD mice that did not get LPS, maraviroc did nothing on any memory test. Social memory and microglia counts did not reach significance either.
So this is a rescue from an induced inflammation hit, not a prevention result. The authors say older models are needed to show benefit “beyond inflammation-driven acceleration.”
HUMAN: maraviroc and artery function
Francisci et al., Open Forum Infectious Diseases, 2019
Randomized crossover pilot. 21 HIV-suppressed patients on protease inhibitors, all at high cardiovascular risk. Maraviroc 300 mg/day for 24 weeks.
Flow-mediated dilation up 2.6% (P = .002).
Max carotid intima-media thickness down about 13% (P = .038).
Pulse wave velocity down 1.0 m/s (P = .022).
Platelet/leukocyte aggregates down as well.
hsCRP, IL-6, D-dimer and the other blood inflammation markers did not move.
Caveats: 21 people, no washout between arms, and HIV patients on protease inhibitors only.
My take: the mouse paper adds a mechanism, not evidence for prevention. The human pilot is small and in a different population, but it is actual human artery data, and the arteries improved without the usual inflammation labs budging.
I’ve been careful, take for a few days then go off for a few days. I take 150 because that’s what came and I don’t know if they work if you bite them in half.
Subjectively they make me feel great, improved mood and outlook. I feel like working out and do better. As with anything it could be placebo but I don’t think so. I was surprised the effect comes on right away, I was under the impression you have to do a couple bottles to get anywhere. This stuff seems good for me.
What made me post is the thing about PWV, according to my scale I’m a year younger than I’ve ever been. I wondered what could be doing that and this could be it. It started happening about the same time
According to my discussions with Claude, if he is correct…iftaking higher doses, he said it makes sense to feel things within only a couple of weeks. ‘HE’ said it would take longer to build muscle but strength comes earlier.
According to Claude, me at 104 pounds, if taking 75mg per day, that is equivalent (ish) to the high dose testing arm…. So this tracks for you because you are taking a fairly big dose, and higher than anyone here, I think.
Getting things into the EU is much harder than many places. Most medications seem to get blocked by the postal system (so you may not have gotten scammed, just blocked by your country’s postal system). You might try EUDoc: New Option for Rapamycin Prescriptions in Europe / EU - #61 by Curious
If it works, please post your results back here (actually either way, if it works or not).
