This is an idea which has been formualted by David Sabatini in his epic podcst with Matt Keiberlein and Peter Attia. In a few words, he told that he was thinking about inhibiting m-TOR by acting upon the upstream signals. He told no more. We had a discussion on this which I could not find, but I’ve been occasionally mulling over this topic. Then, when I heard that the recent Gemini 3.1 Pro may have reasoning capabilities similar to the alpha-fold model. So I decided to ask to him (anthropomorphized).
Q: Consider all the evidence we know on the mTOR biological system, especially so the upstream signals which can activate the mTOR complex systemically or inhibit it. Now select the following which can act on the upstream signals and inhibit mTOR in a fashion similar to rapamycin: 1)specific diet and foods, 2) specific physical activity; 3)specific supplements; 4) specific sleep habits. 4) other non pharmaceutical interventions. Also specify theestimated degree of inhibition.
The answer has been very extensive and went beyond what I originally wanted. Since it is not a short one, I am attaching the PDF. I did not pirsue the loogarithmic model since the server blocked, probably because of the limitations to my free acount.
Rapamycin mimicking scheme.pdf (150.4 KB)