You didn’t get my point: There are papers that found benefits. There are papers that found no benefits. And there are papers that found risks. And when you look at papers that found benefits they’re often low-ish quality (especially poor control for confounders + no dose-response). So overall the case for those drugs is not strong. It does not mean those drugs are bad. But it’s not like statins, SGLT2i or GLP-1RAs for instance.
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BTW, GLP-1RAs are evil. I’ve cursed the person that invented them for seven generations LOL
I might just do a microdose of 1mg weekly for a bit of appetite suppression but NEVER again at doses suggested to lose weight. Using them made me experience what it is like to be 110 years old at only 55 LOL.
A great sign of having at least an average iq is the understanding that your own experiences are not necessarily universal.
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I think the argument for both sides are valid. While the drug classes you list are much better, I still think it’s a net positive and will continue to take Tadalafil because I think the nitric oxide boosting effects are unique to PDE5s and probably part of the reason they would reduce mortality. That being said, I reserve the right to change my mind as more data comes out.
So true. Really, from a quality-of-life aspect these drugs are absolutely amazing.
But I do agree with @adssx that the purported benefits are not as exciting as I think we’d initially hoped. I think he’s correct that any sort of observational study has a huge amount of confounders at play, and that’s definitely made me re-evaluate whether to keep using these medications.
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There’s strong evidence that GLP-1RAs increase depression risk. This might be what @Kelman felt?
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Yes, my criticism is that I feel they’re overhyped vs the current evidence. It would be better to say “if you’re a man, those are great drugs for your quality of life, and, cherry on the cake, they might have some long-term health benefits”.
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No, I wasn’t depressed, but it was weakness to the point of not wanting to get out of bed. P{lus had big GI issues especially heartburn and indigestion. Might have also affected sleep negatively though my poor sleep I think was mainly due from Cialis.
‘Viagra has many benefits, but it does not seem like the drug that will extend lifespans.’
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From the writeup:
My verdict, if I had to guess, is that {Viagra or Cialis} is good for cardiovascular health quite broadly and mildly, and if you’re at high risk of bad cardiovascular outcomes, then it will probably help you to live longer and to live healthier. Moreover, it’s good to take anyway for the treatment and prevention of ED if you’re a man.
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Ah just seeing your post now, anyway I posted it there: Crémieux: Viagra for Life Extension Does it work? I'm doubtful
The good part is that it includes another MR for AD that we missed (or at least I did) and it does not seem harmful.
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