Crémieux: Viagra for Life Extension Does it work? I'm doubtful

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Here it is: Viagra for Life Extension - Cremieux Recueil

In particular, it includes two MR on AD:

• Genetically Proxied Phosphodiesterase Type 5 (PDE5) Inhibition and Risk of Dementia: A Drug Target Mendelian Randomization Study 2025: “After correcting for multiple comparisons, genetically proxied PDE5 inhibition, per one SD lower in diastolic blood pressure, was associated with higher odds of Alzheimer’s disease (OR 1.09, 95% CI 1.07–1.11) and Lewy body dementia (OR 1.32, 95% CI 1.23–1.41), but a trend towards lower odds of vascular dementia across all instruments.”
• Phosphodiesterase-5 Inhibition and Alzheimer’s Disease Risk: A Mendelian Randomisation Study 2025: “No evidence of a causal association between PDE5 inhibition and AD risk was found in the main analyses. Similar findings were obtained in the sex-stratified analysis. Our study uses genetic data to triangulate the evidence and suggests that PDE5 inhibitors are unlikely to decrease the risk of AD.”

So PDE5i probably useless for AD but not harmful (second paper seems better). For LBD: TBD.

[Cole]

Regular use of PDE5 inhibitors is associated with an overall 1.85-fold increased risk for a composite of ocular adverse events, specifically increasing the incidence rate of serous retinal detachment by 2.58 times, ischemic optic neuropathy by 2.02 times, and retinal vascular occlusion by 1.44 times.

[RapAdmin]

Large Study Finds Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

From the writeup: My verdict, if I had to guess, is that {Viagra or Cialis} is good for cardiovascular health quite broadly and mildly, and if you’re at high risk of bad cardiovascular outcomes, then it will probably help you to live longer and to live healthier. Moreover, it’s good to take anyway for the treatment and prevention of ED if you’re a man.

[LukeMV]

I’m starting to lose a little bit of faith in PDE5’s. I still think there is benefit overall, but this is one of those rare drugs that causes annoying side effects for me (bloodshot eyes, acid reflux, and nasal congestion).