Large Study Finds Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

According to a study led by researchers at the Cleveland Clinic, taking sildenafil is tied to a nearly 70 percent lower risk of developing Alzheimer’s compared to non-users.

That’s based on an analysis of health insurance claim data from over 7.2 million people, in which records showed that claimants who took the medication were much less likely to develop Alzheimer’s over the next six years of follow up, compared to matched control patients who didn’t use sildenafil.

It’s important to note that observed associations like this – even on a huge scale – are not the same as proof of a causative effect. For example, it’s possible that the people in the cohort who took sildenafil might have something else to thank for their improved chances of not developing Alzheimer’s.

Full story:

Source Research Paper:

Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease

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This is pretty exciting! What’s not clear is if this is a class effect (same or better effect from Cialis?) or if it’s specific to the molecular structure of sildenafil only.

I think its likely to be all pde5 inhibitors - so yes, Cialis should be similar I think (if the correlation is actually causation).

Maybe. The article and the abstract suggest that it’s the molecular structure of sildenafil interacting directly with amyloid/tau protein, so this may be completely unrelated to PDE5 inhibition. I’m not sure how similar/dissimilar are the molecular structures of sildenafil vs tadalifil, but even minor differences could result in no effect of tadalifil.

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Has anyone adding a PDE5 inhibitor to their stack strictly for longevity benefits?

Thinking of perhaps exploring Cialis (Tadlafil) at low dose, 5 or 20mg daily. It has a much higher AUC than than Sildenafil (Viagara).

A clinical trial in UK is looking at this for dementia/neurocognitive.

Anything that improves my cardio further, is of great interest.

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I got my doc to script me 5mg/day Cialis for longevity. This is coming from my Functional Medicine Doctor (prevention is the philosophy).

I still have a regular doctor for your basic internal stuff, but forget about getting support for prevention.

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Agreed. Sounds like a specific interaction with Tao/ amyloid. I was hoping that it was an endothelial nitric oxide effect, in which case all of the drugs in the class would work, as would pine bark / gotu kola. Might definitely be specific for viagra.

I am hoping it’s Tau/Amyloid too, although improving NOx in general is highly associated with improved cognition. And hopefully NOT just a Sildenafil only pathway.

There a couple of trials with Cialis (Tadalafil) and cognitive:

Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial - Full Text View - ClinicalTrials.gov (Tadalafil, Cialis)

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - PDE5 Inhibitors vs Endothelin Receptor Antagonist - Full Text View - ClinicalTrials.gov (both Viagara/Sildenafil and Cialis)

FYI - Rough pricing from the Indian guys (forget which one): (Note - the “minimum orders” are very flexible… as long as you’re ordering a $100 or more it seems they don’t generally care about the actual minimum order sizes)

Zydalis Tadalafil MD 10mg : $4.5 for each pack of 4 tablets
Minimum order: 50 Packs (200 tablets)

Zydalis Tadalafil MD 20mg: USD $6.2 for each pack of 4 tablets
Minimum order: 50 Packs (200 tablets)

Udzire Udenafil 100mg tablets: USD $19.2 for each pack of 2 tablets
Minimum order: 50 Packs (100 tablets)

Udzire Udenafil 100mg tablets: USD $7 for each pack of 6 tablets
Minimum order: 50 Packs (300 tablets)

I was kind of surprised that my urologist on my last visit in August recommended a small daily dose of tadlafil - 5mg for general urinary and blood health - as prevention not necessarily for ED… which wasn’t an issue. His attitude is it’s good for you. Seems to be good. :wink: The cognitive decline prevention benefit is an added plus!

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That’s a proactive Urologist you have…take it!

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Oh yes! He is young and progressive, and provided the prescription for 12-months - I think it is $10 (after Cigna Insurance discount) for 30 pills take one a day. I would recommend others check with their Urologist on their next visit - or soon!

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I can buy locally Tadalafil, and after insurance coverage, my cost approx $0.156 USD/mg, or $23.40 USD/month @ 150 mg total for the month. Sufficiently low cost to not bother importing.

In your quoting:

Zydalis Tadalafil MD 20mg:** USD $6.2 for each pack of 4 tablets
Minimum order: 50 Packs (200 tablets)

This is approx $0.078 USD/mg.

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Related:

Price is only $0.016 per mg.

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You know, when I read a study like this, it also could be that men who take ED drugs are still having sex and are probably more active and healthier as a result. Just my .2 cents.

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Huntington’s too…I think this is a legit therapeutic target pathway.

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Well, the “large study” was for Viagra.
I have tried both. If insurance is not paying, Viagra is much cheaper.
I prefer Viagra because for me, Tadalafil has an unamusing side effect and that is,
while taking Tadalafil and waking up at 3 am with a woody and having to take a pee, I have to stand there looking at porcelain waiting for my morning glory to wilt.

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True:

https://costplusdrugs.com/medications/sildenafilcitrate-20mg-tablet/

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This is an amazingly well-done study.

One thing I’d recommend that anyone considering PDE5 inhibitors look into closely: ototoxicity.

I suspect strongly it is greatly underreported. What gets reported are mostly the serious events (profound SSNHL, mostly), not minor hearing loss or tinnitus, which could be happening very frequently. Many people might not even report the tinnitus (esp. if it’s a worsening of existing tinnitus) to a healthcare practitioner, and many people wouldn’t notice a minor hearing loss.

One ENT says that PDE5Is are basically giving parts of your inner ear a minor stroke.

You don’t want to be stuck with screaming tinnitus. Be careful.

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Brian - thanks for posting this. I’ve not even heard of ototoxicity before - so its good to hear about and I’ll add some resources:

PDE5 inhibitors and ototoxicity

It definitely seems like something to read up about:

manna2019.pdf (289.3 KB)

and

liu2018.pdf (303.8 KB)