Lactoferrin: A Milk-Derived "Immunoceutical" Reverses the Clock on Inflammaging

  1. That’s incorrect many products in the EU don’t show the exact form.
  2. In any case if it’s native bovine then it is NOT apolactoferrin only and the label is wrong. That’s the problem. Apolactoferrin has iron saturation % lower than 5%.

I’ll email them again…

Here’s their answer:

Thank you for bringing this to our attention.
The product image you saw is an old visual, and we will look into updating it. Our product is hololactoferrin, and the iron saturation remains 10-20% as previously mentioned.

That’s concerning as they said before it was native bovine lactoferrin. It’s also concerning that they sell products with wrong information. And as I posted above, holo lactoferrin seems to be detrimental: Exploring the Multifaceted Neuroprotective Mechanisms of Bovine Lactoferrin in a Cell Culture Model of Parkinson’s Disease 2025:

Conversely, Holo-bLf exhibited pro-oxidant effects and increased α-synuclein accumulation even in absence of rotenone. Overall, these results highlight the differential neuroprotective effects of both Nat- and Holo-form, resulting from their distinct iron saturation level and their ability to modulate protein expression, with the native form emerging as a promising candidate for therapeutic strategies to counteract PD-associated neurodegeneration.

Vitamatic lactoferrin should therefore go to the trash @John_Hemming.

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A third person from Vitamatic answered me (it’s never the same person!):

The iron saturation level of the lactoferrin is 14.6%, which falls within the typical range of 10–20%.
This level of iron saturation indicates that the product is partially iron-saturated (native bovine lactoferrin), meaning it naturally contains bound iron as it occurs in milk, rather than being fully iron-depleted (apo) or fully saturated (holo).

So, same company, three people, three different answers! :man_shrugging: I hope they’re better at manufacturing, testing compounds and securing their supply chain…

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Do you agree with @John_Hemming that “Vitamatic lactoferrin should therefore go to the trash”?

If a supplement company isn’t able to answer what is in their supplement, their supplement should go to the trash, and no one should buy from them.

They are likely buying from a Chinese supplier, unless they told you differently, and do not know what they are selling. However the color indicates that it is unlikely Hololactoferrin, (iron-saturated is noticeably deeper pink to reddish)

I will be using it with blood tests before starting it and 7 days later, but not immediately.

I agree with you, the third answer (native bovine lactoferrin) is the most likely. But their amateurism is worrying.

I am looking at another brand that claims to be freeze-dried bovine lactoferrin.
Gemini: A freeze-dried lactoferrin supplement is generally considered superior to a “regular” (spray-dried) supplement if your goal is maximum bioactivity, as the low-temperature process better preserves the protein’s natural structure.
Several customers have supplied pictures and claim it looks white. It is also supplied in an enteric-coated capsule. I have been putting my Vitamatic capsules in a larger enteric-coated capsule. When I finish my Vitamatic, I think that I will try these, unless another member finds a better one.

Enteric Coated Lactoferrin Supplement - Delayed Release Capsules | Grass Fed Bovine Lactoferrin