A little weekend blog on methylene blue.
As you know from my posts I am a big fan of methylene blue and photomodulation therapy.
I have been using both for many months.
As much as I have liked the results, this video tells me that I have probably underdosed the MB,
To take the doses suggested for therapeutic value starting ~40 mg daily presents a minor challenge, both as to cost and the practical aspects of taking that big of a dose:
“A study showed that low doses (0.5–4 mg/kg) of MB are effective to stimulate mitochondrial
respiration in vivo and safe in animals and humans”
“Surprisingly, a French study involving 2500 patients treated with MB and standard chemotherapy showed no cases of COVID-19 infection”
I took the remaining liquid doses that I had on hand. I put 20 mg MB blue in 8 oz of water.
Not only did it turn my tongue very blue, but had an unpleasant bitter peppery taste going down.
This is not a practical approach for me.
But I noticed a big improvement in energy. I was able to accomplish more in a day than I have for quite some time
I ordered U.S.P grade MB powder from Amazon. I have a small scale again from Amazon that measures down to micrograms. I will use this to measure out 50 mg (Just above the low end of the suggested dose) and will put it in empty capsules.
I believe the YouTube video posted by DeStrider used the first two references below for most of the information. Many of the pictures are pretty much identical
“As reported, both MB and PBM are known to enhance energy production and decrease oxidative stress”
“low dose of MB (1.5 mg/kg) on the first day of TBI”
“depressive illness were significantly improved after receiving 15 mg/day MB”
Table 2
Summary of effects of MB or PBM on neurodegenerative disorders and brain injury
Disease:
Effect of a treatment with MB Effect of a treatment with PBM AD
• Increases functional MRI activity and improves memory retrieval [200]
• Reduces hyperphosphorylated tau, neurofibrillary tangles, and oxidative stress [234, 235]
• Decreases Aβ levels and Aβ-ABAD binding [226]
• Increases the ability of Aβ phagocytosis [236]
• Attenuates the activity and expression of β-secretase, inhibits the formation of neurotoxic oligomeric Aβ, and improves behavioral results [19, 20, 198]
• Improves spatial learning and memory by significantly reducing Aβ burden [236]
• Exerts neuroprotection by activating the
• Inhibits p-tau aggregation and tau-tau interactions [229, 230] ERK/CREB pathway and upregulating the expression of BDNF [237]
• Reduces excessive ROS production [17, 22]
• Upregulates Complex IV activates, heme synthesis and mitochondrial function [226, 231–233] • Restores mitochondrial dynamics [8]
TBI
• Decreases edema and lesion volume and improves behavioral scores [163]
• Neurological improvement [246]
• Increases autophagy [242]. • Increases mitochondrial function, improves blood flow, and reduces swelling [244, 247]
• Inhibits excessive ROS production and attenuates mitochondrial dysfunction, cytochrome c release, and neuronal apoptosis [243]
• Decreases oxidative stress, inhibits inflammation, and attenuates apoptosis [244, 247]
Stroke
• Improves behavioral results after focal cerebral ischemia [16]
• Improves neurological rating scores [4, 255, 256]
• Decreases lesion volume, cerebral edema, and gray and white- matter damage [16, 18]
• Stimulates neurogenesis and improves mitochondrial function [4, 262]
• Increases cerebral global glucose uptake and blood flow [251, 252]
• Preserves mitochondrial integrity [263]
• Increases mitochondrial function [9, 252]
• Attenuates mitochondrial fragmentation and restores mitochondrial dynamics [254]
• Preserves mitochondrial structure and function [253]
• Increases mitophagy and preserves mitochondrial membrane potential [253]
• Decreases protein carbonylation, DNA oxidative damage, and lipid peroxidation [254]
Depression
• Improves the symptoms of patients with severe depression [265]
• Improves depressive symptoms [274–277]
• Selectively inhibits nitric oxide synthase (NOS) [264, 265, 270, 271]
• Improves ATP production and increases activity and expression of mitochondrial Complex IV [208]
PD
• Attenuates dopamine loss and reduces the disruption of mitochondrial function and excessive production of ROS [280–284]
• Reduces cell loss and inhibits inflammatory amoeboid microglia [287–290]
• Improves Complexes I, II, and III activities, reduces free radical production, and improves behavioral results [252, 285]
• Improves speech, cognition, gait, and freezing episodes in PD patients [291, 292]
• Upregulates brain-derived neurotrophic factor (BDNF) expression [286]
• Improves mitochondrial function and reduces oxidative stress [293]
:Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826781/
Alternative Mitochondrial Electron Transfer for the Treatment of Neurodegenerative Diseases and Cancers: Methylene Blue Connects the Dots - PMC
The Potentials of Methylene Blue as an Anti-Aging Drug - PMC)
“Google Scholar?
journal=Substantia&title=A+cohort+of+cancer+patients+with+no+reported+cases+of+SARS-CoV-2+infection:+The+possible+preventive+role+of+Methylene+Blue&author=M.+Henry&author=M.+Summa&author=L.+Patrick&author=L.+Schwartz&volume=4&publication_year=2020&pages=888&doi=10.13128/Substantia-888&”
