Sorry, what does this mean?
Just thinking out loud:
You could do both if you could measure how much mTORC1 is inhibited. I think it’s more important to validate the therapy rather than measure the dose-response (on mTORC1). There might be some systemic signal since apparently brain mTOR might be inhibited by systemic use, but there’s controversy with this (i.e i’m not sure if TSC tumors which are treated with everolimus are past the BBB, and some study didn’t find any brain mTOR inhibition).
Thanks
What are your suggestions for how to currently deal with question like
each individual finding how high he or she can dose rapa / how long washouts need to be / how helpful thing like like acarbose that might help raise mTORC2 are, etc, etc
I think you would be putting the cart before the horse. Validating mTORC1 as a biomarker – creating a biomarker – is most important. Then it could be like LDL-C. Or am I wrong here?
If it could be use for retrospective analysis of large datasets on outcomes that would be better but I don’t know if it’s possible as I don’t know anything about it. But yeah if you base on what I know mouse studies and other animals with mTORC1 that’s fine, but if you can measure it in humans, feels like that’s not aiming high enough IMO.
I think maybe you missed the fine print. It was a method for measuring mtorc2 not mtorc1 inhibition that was discussed. Mtorc2 has been very elusive so far to measure and there’s many reasons to steer clear from inhibition.
Sorry, typo. Hard corers — more serious users who spend more time and money on testing various biomarkers.
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I don’t think it’s much of a difference either or and the pipeline suggested should be treated as a hypothesis to begin with, i.e not determined to measure something expected in one shot.
Eventually after discussing the matter with ChatGPT it seemed that the easiest proxy to measure would be insulin resistance and glucose spikes — they’re the canary in the mine, followed by an explosion in lipids. So I’m getting me a glucose monitor instead of the fancy mtorc2 lab work.
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Very good news, I’m glad to see that Chinese companies are faster than Western ones.
Edit: Thanks RapAdmin for the heads-up.
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its very good news, but they will not reach the market before at least 5 years 
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