Inflammaging Is Chronic, Stealthy and Can Be a Serious Threat to Your Health (WSJ)

#1

This is a story by Alex Jenin, who did the earlier WSJ story on rapamycin: Rapamycin starting to go mainstream. Article today in Wall Street Journal

Its a reasonable summary of the world of inflammaging, and includes references to colchicine and rapamycin:

Treating chronic inflammation can be tricky.

A drug has to tamp down inflammation without blocking the immune system. Some patients who have atherosclerosis or are at high risk of cardiovascular disease are treated for inflammation with a low-dose version of the drug colchicine, approved by the Food and Drug Administration in 2023 for that use. The drug has been used for years to treat gout, a joint-pain disease.

Researchers are studying whether other drugs, including GLP-1s, can lower inflammatory markers. And Novo Nordisk and CSL Behring are testing potential anti-inflammatory medications in patients who have cardiovascular disease or are at high risk.

Some people have experimented with taking medications such as metformin and rapamycin to target inflammaging. Both drugs, approved by the FDA for other uses, have shown potential to target inflammaging, but more research in humans is needed.

Otherwise, the best ways to ward off inflammaging today? All the things you should be doing anyway: exercising consistently, not smoking, maintaining a healthy weight and eating healthfully.

Some research suggests the Mediterranean diet, which emphasizes nuts, whole grains, fish, fruits and vegetables, is particularly protective against inflammation. Red meat, by contrast, promotes inflammation.

Most important for brain health is seven to eight hours of sleep a night, said Tanzi. The brain gets rid of amyloid that triggers inflammation then, he said.

Full story here: Inflammaging Is Chronic, Stealthy and Can Be a Serious Threat to Your Health (WSJ)

Related Reading:

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#2

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Optimal lifestyle patterns for delaying ageing and reducing all-cause mortality: insights from the UK Biobank (open access)

Results

The findings indicate that, in most cases, maintaining an anti-inflammatory diet, engaging in at least moderate physical activity, and ensuring healthy sleep conditions are associated with delayed physiological aging (Cohen’s d ranging from 0.274 to 0.633) and significantly reduced risk of all-cause mortality (HR-SPA: 0.690, 95% CI: 0.538, 0.884; HR-OPA: 0.493, 95% CI: 0.293, 0.828). These effects are particularly pronounced in individuals under 60 years of age and in women. However, it was observed that the level of physical activity recommended by the World Health Organization (600 MET-minutes/week) does not achieve the optimal effect in delaying biological aging. The best effect in decelerating biological aging was seen in the high-level physical activity group (≥ 3000 MET-minutes/week). The study also highlights the potential of biological age acceleration and telomere length as biomarkers for predicting the risk of mortality.

Conclusions

Choosing healthy lifestyle patterns, especially an anti-inflammatory diet, at least moderate physical activity, and healthy sleep patterns, is crucial for delaying aging and reducing mortality risk. These findings support the development of targeted interventions to improve public health outcomes. Future research should focus on objective assessments of lifestyle to further validate these associations.

Related:

The new index, an empirical dietary inflammatory index (eDII), is based on 8 pro-inflammatory components (red meats, processed meats, organ meats, other fish, eggs, sugar-sweetened beverages, tomatoes, and refined grains ) and 8 anti-inflammatory components (leafy green vegetables, dark yellow vegetables, fruit juice …

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Open Access Paper:

https://www.sciencedirect.com/science/article/pii/S2049080119301311

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#3

I think the core of this is the presence of senescent cells that you can measure with IL-6 levels and the easiest way of doing that normally is via measuring CRP.

I think there may be an issue with IL-6 not always converting to CRP, but it is a good start.

It has to be the baseline uninfected levels, however.

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#4

Remember that statins, Bempedoic Acid, and Ezetimibe effectively lower chronic inflammation. Not to mention cholesterol.

I wonder if there is a strong link between cholesterol and inflammation. It wouldn’t surprise me at all if they are interrelated.

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#5

Dr. Rudolph Tanzi: Proven Brain-Protective Supplements For Longer Life

Rudolph E. Tanzi, PhD

Joseph P. and Rose F. Kennedy Professor of Neurology, Harvard Medical School
Vice-Chair, Massachusetts General Hospital Neurology Department
Co-Director of the McCance Center for Brain Health, Massachusetts General Hospital

  1. Tru-Niagen (nicotinamide riboside; one as directed)

  2. Percepta: (Cat’s Claw extract/oolong tea extract/black currant;) (as directed); DO NOT USE IF YOU ARE ON A BLOOD THINNER OR HAVE ABNORMALLY LOW BLOOD PRESSURE

  3. Vegan Omega 3: (as directed)

  4. Quercetin (as directed)

  5. Fisetin (as directed)

  6. TUDCA (as directed)

  7. Ashwagandha (take one in the evening – can make some sleepy)

  8. Vitamin D3 (1000 IU): (I currently take 2 per day during the pandemic)

  9. Methyl-B12 Plus (as directed)

  10. Coenzyme Q-10 (especially if on a statin, e.g. Lipitor; as directed):

  11. Selenium (as directed)

  12. Nordic Natural Probiotic plus Prebiotic (one as directed)

Edited list —- I got a copy of his current list as of October 27 2024. A few changes.

Brain Supplements Taken Daily by Dr. Rudy Tanzi

Disclaimer:

These are the brain supplements that I personally take on a daily basis. The evidence of potential benefit for most of these supplements comes solely from research laboratory experiments. The natural products claimed to be contained in these supplements were found in my lab to reduce Alzheimer’s pathology based on screening of our 3D human neural-glial cell culture models of Alzheimer’s disease (Alzheimer’s-in-a-Dish™).

We have no evidence that the natural products in this list of supplements carry out similar effects in patients since clinical trials have yet to be performed. We are currently fundraising to carry out such clinical trials.

This list is not intended to represent clinical recommendations from either myself, Harvard University, or Massachusetts General Hospital. I have chosen these supplements based primarily on evidence from research lab models. In making these suggestions, I am expressing only my own personal views.

No one should start taking any supplement without first checking with his or her personal physician. Some supplements can be dangerous for people with certain pre-existing medical conditions and supplements can interfere with some prescription drugs. Supplements can also affect different people differently. The FDA has reviewed the ingredients of these supplements to determine whether they are safe to consume, but new data regarding the safety of supplements are being generated on a routine basis and may change over time. Importantly, no US regulatory authority has reviewed the long-term safety or ability of these supplements to address cognition, dementia, Alzheimer’s disease, or human brain health generally.

Supplements should only be purchased from trusted retailers and brands; testing has shown that many supplements are contaminated with unlisted ingredients and/or do not contain the amount of the supplement listed on their label.

Urolithin A (one per day)

Fisetin (one per day)

https://www.amazon.com/Life-Extension-Bio-Fisetin-30-Count/dp/B08M99BR1N/ref=sr_1_1?crid=3CHU7D9LK2Y1V&keywords=bio-fistein&qid=1668795295&rdc=1&s=hpc&sprefix=bio-fistein%2Chpc%2C87&sr=1-1

Tru-Niagen (nicotinamide riboside; one per day)

https://www.truniagen.com/product_page.html?utm_source=google&utm_campaign=brand&ads_cmpid=1691853737&bidkw=chromadex%20niagen&dvc=m&h=http://clickserve.dartsearch.net/link/click?&ads_adid=71634091888&ads_matchtype=e&ads_network=g&ads_creative=328836649902&utm_term=chromadex%20niagen&ads_targetid=kwd-361547939727&utm_campaign=&utm_source=adwords&utm_medium=ppc&ttv=2&gclid=EAIaIQobChMI7euq3b7v5QIVmP_jBx1FuAgIEAAYASAAEgIu7vD_BwE

Percepta: (Cats Claw extract/oolong tea extract/black currant;) (one per day);

(DO NOT USE IF YOU ARE ON A BLOOD THINNER)

Https://www.Perceptabrain.com

Note: R. Tanzi is a co-founder of Cognitive Clarity

Quercetin (one per day)

Ipriflavone (one per day)

https://www.amazon.com/BlueBonnet-Ipriflavone-Supplement-60-Count/dp/B00098IHA8/ref=sr_1_3?dib=eyJ2IjoiMSJ9.Oi_SZz7X5IoQc7WHlf7e9bYMMj6maXZQmMSTjuWE-RXlJAUrZEnLUhHwC51Nyac2Pvfx_Xqv1HO1s9MTLF9f7eBob4-U6BGZgP2Qu7pFFA_vowu_Ss6tEri8VZoArleeM0zYkjZAUf6UecPlYd1edK3Vq4UQhzMllz4Lb5uODlnkFOGaRV4rLXIuh14DqnmuMe2nRjYrv_cz179O2Up0-Y_EVGQ91KwvUPnHKu-SdmCc66H2c_w4abbhJtJMqsfEAMgfeTxEEMyCcQR28pkbxfUgXLjiGTqn3VgKzPzJUJc.N6mFcaUFG1-sfJfkVI93o7wD_wbC9vCM-EDBeNEwBq4&dib_tag=se&keywords=ipriflavone&qid=1707935799&sr=8-3

Baicalin (one per day)

https://www.amazon.com/Supersmart-Scutellaria-Baicalensis-Alternatives-Vegetarian/dp/B01G5MZJWK

Vegan Omega 3 (DHA/EPA): (two per day)

https://www.amazon.com/Spectrum-Essentials-Vegan-Omega-3-Softgels/dp/B00E99YKAY

or,

If you prefer omega 3 from fish oil:

https://www.amazon.com/Nordic-Naturals-Clinically-Support-Healthy/dp/B002CQU4YW/ref=sr_1_6?crid=CW7SLMO72JV3&keywords=nordic%2Bnaturals%2Bepa&qid=1674935005&sprefix=nordic%2Bnaturals%2Bep%2Caps%2C114&sr=8-6&th=1

MegaFood Balanced B Complex (one per day) – vitamins - not tested in lab

https://www.amazon.com/dp/B00028ONPI?psc=1&ref=ppx_yo2ov_dt_b_product_details

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