Ketogenic diet on inflammation-related markers: IL-6 -7% TNF -9%; and no changes in CRP, IL-8 & IL-10)

"The effect of a ketogenic diet on inflammation-related markers: a systematic review and meta-analysis of randomized controlled trials " 2024 Nutrition Reviews, with 44 RCT studies included
Takeaway: meaningful improvement in 2 biomarkers IL-6 -7% TNF -9%; and no changes in CRP, IL-8 & IL-10)
Intervention variation: The duration of the ketogenic diet varied, but some short-term options (≤8 weeks) were effective.
Participants: Focused on adults with various health conditions, suggesting broader applicability.
Main finding: A ketogenic diet potentially reduces inflammation, measured by TNF-alpha and IL-6 levels. Important caveat: Reduction may be influenced by individual factors like age, weight, and adherence to the diet.

Keto Diet: a high-fat diet?
Fat: 70-80% of daily calories
Protein: 20-25% of daily calories
Carbohydrates: 5-10% of daily calories



The effects of ketogenic diet seem almost uniformly healthful, but it is hard to know how to evaluate papers like this because they don’t report average plasma ketone levels. Perhaps the benefits increase with high levels (to a limit, of course), but perhaps they flatten out at a low molarity, or perhaps they have a U-shaped curve. These papers hint at benefits, but offer little guidance on the ketone levels needed.

My other complaint about these types of papers is the keto diet used: the classical diet, in grams (not calories) of macros, is 3:1 for fat: (protein+carbs). The diet described above is closer to 1:1.

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