Metformin decreases inflammation - an interesting tidbit from Peter Attia’s podcast on inflammation that came out yesterday (#301, AMA #59). I think it did this for me during an inflammation-driven health crisis early last year, and continues to help me with that condition.
From the podcast, under the category of drugs that decrease inflammation:
Glucose-lowering drugs that are used to treat type 2 diabetes:
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Various diabetes medications, including SGLT2 inhibitors, GLP-1 agonists, DPP-4 inhibitors, thiazides, sulfonylureas, and particularly Metformin, have shown to reduce inflammation.
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These effects might be due to direct anti-inflammatory actions or indirectly through improvements in metabolic health and weight loss.
Metformin and Geroprotection:
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One of the arguments of people who believe that metformin is geroprotective is that this is one of the pathways that metformin targets is directly targeting inflammation.
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This characteristic of Metformin is viewed as extending beyond its primary role in blood sugar regulation, possibly affecting processes like cellular senescence and systemic inflammation.