Metformin Decreases Inflammation

Metformin decreases inflammation - an interesting tidbit from Peter Attia’s podcast on inflammation that came out yesterday (#301, AMA #59). I think it did this for me during an inflammation-driven health crisis early last year, and continues to help me with that condition.

From the podcast, under the category of drugs that decrease inflammation:

Glucose-lowering drugs that are used to treat type 2 diabetes:

  • Various diabetes medications, including SGLT2 inhibitors, GLP-1 agonists, DPP-4 inhibitors, thiazides, sulfonylureas, and particularly Metformin, have shown to reduce inflammation.

  • These effects might be due to direct anti-inflammatory actions or indirectly through improvements in metabolic health and weight loss.

Metformin and Geroprotection:

  • One of the arguments of people who believe that metformin is geroprotective is that this is one of the pathways that metformin targets is directly targeting inflammation.

  • This characteristic of Metformin is viewed as extending beyond its primary role in blood sugar regulation, possibly affecting processes like cellular senescence and systemic inflammation.