@Jonas 500mg in AM, most days except Rapa dosing day.
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Just add them to yogurt and let them sit for a while. They may not look the best but do taste fine.
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I think just 6 will outperform most stacks:
The important ones:
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Rapa
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Acarbose
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Glycine
The less confidence ones:
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Taurine
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Carnosine
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NAC
If I had to choose a few more to get to 10:
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sulforaphane (edit: replaced creatine)
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astaxanthin
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lutein
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hyalauronic acid
Probably something to lower LDL deserves a place but I don’t really understand if there’s any “no brainer” such interventions without side effects. And lack of animal longevity evidence, though partly because mice die much less of CVD than humans.
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Rapamycin can cause diabetes and death as a possible side effect so by your logic we shouldn’t take it either. I don’t believe there is any substance known to man that doesn’t cause side effects in at least some people, psychosomatic or not.
Rather than look at possible downsides, I look at the net benefit of an intervention.
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@SNK
There’s been some mention here that taurine and beta-alanine interfere with each other. Do you think that taurine may interfere with carnosine?
@stealle
Do you think that the aged garlic is better than beets or blueberries for lowering BP? Dropping your systolic by 45 is remarkable.
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I wouldn’t know… in my case I take taurine in the evening and take carnosine and beta alanine in the morning. I also take carnosine and ornithine before bed, but that also is about three hours later than taurine.
i see Peter Attia can only think of 9 supplements…
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Hi Matt, Can you explain more about sulforaphane vs creatine. I couldn’t find much in a search. Assuming any resistance excercise, I would consider creatine essential.
I just realized I had left out sulforaphane and think creatine is the least interesting of the rest for lifespan extension.
Sullforaphane has been talked about as being anticancer, though I haven’t looked that deeply and there’s no mice lifespan trials. Anticancer properties of sulforaphane: current insights at the molecular level - PMC
Since it’s cheap and comes from broccoli, i think it’s interesting.
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Though maybe I should have replaced astaxanthin, while it had ITP success the dose was way higher than we can get through available supplements.
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Yes, it’s hard to prioritize and sulforaphane certainly has promise but creatine also has other potential benefits. And considering sarcopenia as a major risk in aging, I wouldn’t drop creatine.
It would certainly be of interest to know if astaxanthin does anything at any practical dose to buy.
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The ITP is doing another round of studies on astaxanthin. The first study equated to about 3grams per day, and I think the new round is going to be equivalent to about 800mg per day (for humans). It seems they are not too hopeful about really low dosing that is really the only option due to cost right now (ie, under 100mg/day).
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My astaxanthin capsules (NOW brand) are 4 mg. So I would need 200 to get to 800 mg. If such low doses are unrealistic for benefit, why the disconnect with what supplement makers are putting on the market?
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It was also my understanding that the ITP and Dr Miller consulated with supplement makers on what would be reasonable doses to test, so why would they test doses that are so different than what is on the market?
They choose the dosing to get the best possible result. Their goal is to find the most effective doses (and initially choose the dose that the experts feel is the most likely to result in a positive life extension).
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Since the ITP used synthetic astaxanthin and this article says that natural astaxanthin could be from 14-90 times more potent maybe the difference isn’t as great as it looks at first glance.
I would not put much value in that article… I believe it was written by a consultant (or a person who gets money from) the “natural astanxanthin” industry.
In fact there are many reasons to think the opposite may be true, that the synthetic is better than the natural. See this thread: Astaxanthin, Natural vs. Synthetic - Your Thoughts?
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I do think aged garlic is better. I will say though that I’m sure the biggest drop in my blood pressure was a result of lifestyle changes (diet/weight loss and exercise). I started taking aged garlic to help reduce my blood pressure quicker than I could lose the weight. It did help some within the first week of taking it. I just keep taking it but I might trial without it in the near future. Especially since I started taking the nitric oxide product from Berkeley Life. It actually works and proven to work based a saliva test sticks unlike beet powder, citrulline or arginine. I might try to include my blueberries in my diet!
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Thanks, just reviewed. Indeed it makes it difficult for us experimenters when it’s so hard to try out what the ITP did with astaxanthin or even know if it’s safe in humans. Any idea on what blood biomarkers would improve with astaxanthin?
Did you feel anything from taking 400 mg? Or notice changes in your blood tests?
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