Then there is this study where no statistically significant result was found between topical HA and placebo. They of course try to spin it positively in their abstract and conclusion as it is a company-funded study.
Furthermore, it is difficult to assess the improvement of a topical agent because these are usually subtle effects that might be difficult to capture; other studies have reported issues.28, 31,32 Additionally, the grading scale used to measure efficacy was not sensitive enough to detect differences between the active group and the placebo group. Our study duration was only 60 days, which might not have been long enough to assess the potential of the active topical ingredients to improve skin aging on the neck. Lastly, one of the limitations of the study was the small sample size.
Taurine and Coffee are synergistic. That’s what I do. I scoop 6 g of nutricost powder into my second coffee of the day which I take several hours after my first coffee which has glycine and collagen.
I appreciate the idea! After my battle with creatine, I’ve learned I’m pretty sensitive to taste, but there is a chance this might work for me.
I’m taking 6 capsules with my other evening pills and am now used to throwing back handfuls of them. If I should ever start taking them earlier in the day, I”ll give the powder in a drink a try. Thx again
Have not heard of that option, so thanks. In another thread, the hive mind helped me figure out a way to tolerate creatine powder. For me, the magic sauce is in my tangy soy yogurt
I have to say, I am very impressed with Dr. Brad Stanfield’s new microvitamin+ powder. Tastes good too. He’s going to add more glycine in the next version of it.
It’s a great idea but given mixing and distribution issues it seems fairly unlikely that you’re getting the listed amount of each ingredient in any given scoop
Achieving uniform distribution of each ingredient in every scoop of a multivitamin powder—especially one containing both macro-ingredients (like collagen peptides and creatine) and micro-ingredients (such as vitamins and TMG)—is a significant challenge in powder formulation. Here’s an overview of the factors influencing this uniformity and the research supporting these insights:
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Challenges in Achieving Uniform Scoops
1. Particle Size and Density Differences: Ingredients like collagen peptides and creatine have different particle sizes and densities compared to fine vitamin powders. These disparities can lead to segregation, where heavier particles settle at the bottom and lighter ones rise to the top during storage or handling .
2. Electrostatic Properties: Some powders can develop electrostatic charges, causing them to cling to equipment or other particles, leading to uneven distribution .
3. Mixing Techniques: Standard mixing methods may not achieve the desired homogeneity, especially when combining ingredients used in vastly different quantities. Advanced mixing techniques, such as geometric mixing or the use of specialized equipment, are often required to ensure uniformity .
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Research and Industry Practices
• Blend Uniformity Studies: Research indicates that achieving uniform blends, particularly in formulations with low-dose active ingredients, requires meticulous mixing and validation processes. Techniques like near-infrared (NIR) spectroscopy are employed to monitor blend uniformity in real-time .
• Continuous vs. Batch Blending: Continuous blending processes have been shown to produce more homogeneous blends compared to traditional batch blending, especially when dealing with multiple ingredients of varying properties .
• Agglomeration Techniques: To improve uniformity and prevent segregation, manufacturers may use agglomeration methods, which involve forming larger, multi-ingredient granules. This approach helps maintain consistent distribution of ingredients in each scoop .
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Implications for Consumers
For end-users relying on a scoop from a jar:
• Macro-Ingredients: Ingredients present in larger quantities (grams per serving) are more likely to be evenly distributed, assuming proper mixing.
• Micro-Ingredients: Ingredients present in smaller quantities (milligrams or micrograms per serving) are more susceptible to uneven distribution, potentially leading to inconsistent dosing per scoop.
• Best Practices: To mitigate segregation, it’s advisable to shake or stir the container thoroughly before each use. However, this may not fully ensure uniform distribution of all ingredients.
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Conclusion
While manufacturers employ various techniques to enhance blend uniformity, inherent challenges persist, especially in formulations combining ingredients of diverse physical properties and concentrations. Consumers should be aware of these limitations and consider them when dosing, particularly for ingredients where precise intake is crucial.
So while it’s possible to achieve uniformity per scoop it seems very challenging under these circumstances. And I’m not convinced Dr. Stanfield appreciates the magnitude of this challenge. At one point he was asked about it on Discord and his response was just something like “the product is mixed well in the factory.”
The COA certifies that the listed amount of each ingredient is in each scoop (after it has been delivered to the consumer)? Because something like that would be required
