β-Hydroxybutyrate suppresses colorectal cancer

More good news on cancer prevention strategies / therapeutics:

the research paper:

https://www.nature.com/articles/s41586-022-04649-6

I have read a little about exogenous ketone products over the past few years, and seen a lot of hype in the market for these products, but had not seen much in terms of research that would backup the value of these products relative to their high cost.

This is the first really good research that I’ve seen (but I haven’t looked much to be honest). Is there anyone out there with more knowledge and expertise in this area who can comment on the value of these types of products in this application?

Here are some overviews and articles I’ve seen on exogenous ketones:

I’ve got hundreds of papers on ketones, both endogenous dietary/fasting (what I do) and exogenous (just a quick “hit”) and health benefits.

Talking with many researchers, inducing ketosis diet/fasting is far superior, but of course, way harder to implement in practice.

But this is a Rapamycin forum. :zipper_mouth_face:

2 Likes

I know that taking exogenous ketones might help you get into ketosis more quickly, for those following or trying to follow a keto diet. Its just that this is the first real paper I’ve seen that suggests significant benefits from a health perspective of the exogenous ketones.

I know they are expensive as they are currently marketed - so still not at all obvious if they are worth the trouble, given anyone can go on a keto diet.

Am I missing anything here on the issue of supplementing with exogenous ketones (powders and drinks)?

Seems like a high price, for pretty minimal benefit

Still early days for exogenous ketones.

“Although preliminary results are encouraging (ME: raising blood BHB, reducing glucose, maintaining lipids), further studies are needed to determine if oral ketone supplementation can produce the same therapeutic benefits as the classic KD in the broad-spectrum of KD-responsive disease states”

3 Likes