I realize that the vanity of people, myself included, leads them to do expensive things to their skin. In most cases, the hype just doesn’t live up to the expectations and expenses.
My observation from being married for 53 years is; the skin care products, probably thousands, my wife purchased over the decades accomplished more by the placebo effect she was experiencing than actual observational improvements that I saw.
Of course, what people choose to do with their money is their business, but I wouldn’t put skincare products very high on my priority list. (Unless there is some underlying skin condition that needs to be treated.)
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Dr. Brad weighs in on reducing skin aging.
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Cosmetic and histologic changes on photoaged skin were evaluated after using immunostains for Type I collagen, Type II collagen, and glycosaminoglycan (GAGS). Investigators found that the combined retinol, tripeptide, and glaucine containing cream was effective in improving signs of photoaging on the face and neck.1
The 20 study participants were 18 years and older and underwent biopsy at baseline and after 3 months of treatment. The average age of participants was 60 years and 90% were female. Patients stopped using other cosmetic products and tanning for the duration of the study.
The study cream, which consisted of 0.2% pure retinol, 2.5% tripeptide concentrate, and 5.0% glaucine complex (Tripeptide-R Neck Repair, Skinceuticals), was used for 90 days by participants in the open-label, blinded clinical trial. The cream was formulated with a hydrating retinol that was encapsulated with timed release and glaucine specifically formulated for thinner neck skin.
Reference
- Rao S, Goldberg D. Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin. J Cosmet Dermatol. 2023; 00: 1-4. doi:10.1111/jocd.15945
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The before/after pic of the face is not very impressive. I think the before looks better than the after.
One can do better with tretinoin or tazarotene.
https://onlinelibrary.wiley.com/doi/10.1111/jocd.15945
I’m skeptical of anything coming from SkinCeuticals. These are the same people charging $200 or more for 30ml of a topical L-ascorbic acid serum of dubious efficacy that you can make at home for like $2.
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I didn’t see any reference to skinceuticals… did I miss it in the paper?
the authors are from this organization, and they don’t mention any commercial ties/COIs:
1Skin Laser & Surgery Specialists, A
Division of Schweiger Dermatology
Group, Hackensack, New Jersey, USA
2Icahn School of Medicine at Mt. Sinai,
New York City, New York, USA
Correspondence
David Goldberg, MD, JD, FAAD,
Schweiger Dermatology Group-Medical
Plaza, 20 Prospect Ave Suite 702,
Hackensack, NJ 07601, USA.
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Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents
Aging is a complex physiological process that can be accelerated by chemical (high blood glucose levels) or physical (solar exposure) factors. It is accompanied by the accumulation of altered molecules in the human body. The accumulation of oxidatively modified and glycated proteins is associated with inflammation and the progression of chronic diseases (aging). The use of antiglycating agents is one of the recent approaches in the preventive strategy of aging and natural compounds seem to be promising candidates. Our study focused on the anti-aging effect of the flavonoid hesperetin, its glycoside hesperidin and its carbohydrate moieties rutinose and rhamnose on young and physiologically aged normal human dermal fibroblasts (NHDFs). The anti-aging activity of the test compounds was evaluated by measuring matrix metalloproteinases (MMPs) and inflammatory interleukins by ELISA. The modulation of elastase, hyaluronidase, and collagenase activity by the tested substances was evaluated spectrophotometrically by tube tests. Rutinose and rhamnose inhibited the activity of pure elastase, hyaluronidase, and collagenase. Hesperidin and hesperetin inhibited elastase and hyaluronidase activity. In skin aging models, MMP-1 and MMP-2 levels were reduced after application of all tested substances. Collagen I production was increased after the application of rhamnose and rutinose.
Full paper (Open access):
Past link / discussion regarding Hesperetin: Hesperetin promotes longevity and delays aging via activation of Cisd2
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I am always curious with these as to how much these molecules are linked to HDAC inhibition. I think Rutin is an HDACi, whether Rutinose (which is prepared from Rutin) is or isn’t I don’t know.
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It was in your original link.
The study cream, which consisted of 0.2% pure retinol, 2.5% tripeptide concentrate, and 5.0% glaucine complex (Tripeptide-R Neck Repair, Skinceuticals),
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May I ask if there are any good ways to prevent rough pores
Mesobotox shrinks pores and gives you smooth skin without affecting mimics.
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Also called “Microbotox”, or “micro droplet botox”…
@LaraPo Is this a type of mesotheapy that you might do yourself? I have no idea as to whether you can purchase the botox easily if you wanted to do it yourself. It seems its available from the usual Indian suspects, this ad suggests 13,000 rupees, or around $160 US for 100iu.
Realself.com suggests:
Micro Botox (also called MesoBotox) refers to the technique of injecting Botox superficially, into the skin rather than into muscle. This is primarily done to tighten pores, reducing oil and making the skin appear smoother, though it may also improve the appearance of redness and flushing from rosacea. However, many doctors on RealSelf recommend other treatments, such as lasers and microneedling, instead of Micro Botox—or in addition to it—for best results.
The dilution and the number of units is the same as for traditional Botox injections, but the Botox is dispersed over a larger area. “Micro Botox is usually injected in the T-zone area and through the entire face: in the forehead, cheeks, nose, and chin area,” says Dr. Usha Rajagopal, a San Francisco plastic surgeon, in a RealSelf Q&A. Micro Botox doesn’t last as long as traditional Botox, with follow-up treatments needed within two to four months for continued effects.
Papers on the topic:
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Yes, it’s something that is easy to do at home. However, 100 iu is a big quantity enough for several people. Once opened, has to be used immediately. There are many meso cocktails, vitamins + Botox, mixed together, that are quite popular. And you don’t need to buy such big quantity.
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Yes, 100 iu is probably enough for two completely frozen faces. For mesobotox you greatly dilute botox, so I believe 10 iu are enough for pores.
Botox once prepared needs to be used immediately or refrigerated for up to several weeks, but it will loose some potency…
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Interesting… it seems 50iu at $120US is the minimum size container sold (from a cursory search on Indiamart).
Doctors usually prepare botox and use it for several patients in a row… it needs to be used in hours.
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But you’re saying you could refrigerate it and use it over a few weeks… but I guess that doesn’t help much (since you aren’t going to redo the injections in a few weeks) - so perhaps people could share the purchase with a friend … It seems the quantities in these vials are too much for individual use, doing mesobotox at home. But at $120 or so per vial, vs. $500 to $600 for the treatment in a dermatologist’s office, people may find its fine to just throw away what they don’t use.
Reading around a bit more… I see people also use Microbotox for the backs of hands:
Botox
That’s right — you can get botox in your hands. This famous wrinkle relaxer can restore a youthful plumpness to your hands in just 30 minutes, and the results last for months.
and
When treating patients’ hands with Botox, the amount of Botox required per hand is proportional to hand size, which is proportional to foot size. So you can tell how much they need over the phone, simply ask patients what size shoes they wear. Very roughly, for a male patient, a • size 8 shoe means each hand needs at least 80 units, • size 10 shoe means each hand needs at least 100 units, • size 12 shoe means each hand needs at least 120 units. So, it is true what they say about guys with big feet… they need more Botox for their hands. Kevin C. Smith, MD, FRCPC Canada Dr. Barankin is a dermatologist based in Toronto, Canada. He is author-editor of five books in dermatology, and is widely published in the dermatology and humanities literature. He is also co-editor of Dermanities (dermanities.com), an online journal devoted to the humanities as they relate to dermatology.
Source: Breaking Bad News, Tips for Using Botox on Hands, and More
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Yes, you could refrigerate, but it looses potency and becomes unpredictable… you also need to repeat the pore treatment every 9-12 weeks, so refrigeration is not an option. Yes, find several friends and DIY might be an option.
edit: my husband said you would need 10-30 iu for pores depending on the treated area and you could potentially use the remaining for mesobotox brow lift (20-30 iu) if you are really daring DIYer (I think he was being cynical not that this is medical advice 
).
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Some research / clinical application discussion on this:
Open Access:
Discussion on this:
prs.0000000000001840.pdf (373.7 KB)
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I order OneSkin via ShipItTo from Europe. Quite straightforward
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