I bought a bottle for the face, supposed to use it twice a day. I’ve been using it once, because lazy. I can easily see the difference. It works.
I’d put before and after pics, but they’re on my phone and I have a problem with tech. It would take at least half hour. I need to run instead.
It definitely works. The difference was last quite stark in my case.
Are you guys talking about OneSkin? Could you link to the product
Yup, that’s the one.
Is Pep 14 part of OneSkin facial creams?
No I don’t believe so.
It is OneSkin’s peptide. Their paper is here: Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models
Pep 14 is a Oneskin peptide, but I think its a new one they are testing. I don’t think it (pep14) is in the current product, which has the “OS-1” peptide.
That has always been peptide 14. Here is their first paper of 2020. Senotherapeutic peptide reduces skin biological age and improves skin health markers
BTW They say that it’s Decapeptide-52
Decapeptide-52 is a synthetic peptide consisting of alanine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine and tryptophan
Here is some other info on that https://www.fightaging.org/archives/2020/11/data-on-oneskins-peptide-14-a-topical-senotherapeutic-in-human-skin-models-and-skin-biopsies/
Nira just released the second generation of their at-home laser called Nira Pro. It has a larger head and is easier to use.
You do realize that none of this sh*t is actually worth the money? (Sorry! Maveric is training me:sweat_smile:) Diet, exercise, and staying out of the sun are much more effective. Some people look young into relatively old age while others, movie stars, etc with enough money for the most expensive supplements, medicines, procedures, etc. cannot hide the unhealthy, gluttonous lifestyle they chose to lead.
And then there’s Tom Cruise…
I wonder what nickname he uses here on this forum. 
My mistake. I’m glad they’ve been published. I remember an interview with one of the founders before they launched the product. She was explaining that the peptide extended nematode worms lifespans by something like 70% and how they decided to move into skin care because it was so time consuming and costly to test the peptide as a drug.
It would still be interesting to see if it could be developed as something you could take orally.
You’re right… its confusing, sometimes they call it OS1, other times peptide 14, I wish they’d keep their nomenclature consistent.
That particular device uses a 1450nm laser diode to heat the dermis to 46ºC (115ºF) to trigger the release of heat shock proteins so I guess using water at that temperature would do the same.
They explain it here: The Technology Behind NIRA
Note that this is different than photobiomodulation used by red and near IR (780, 850 nm)
UPDATE: I just tried to put my hands in 46ºC water for a few seconds at a time and it’s supportable.
I will try to find if there are some studies on that.
Reviews of the previous generation don’t seem to spectacular:
https://www.amazon.com/NIRA-Skincare-Laser-Serum-Bundle/product-reviews/B08P2DZB4X
Does 46ºC water temperature = 46ºC dermis temperature? I’m doubtful. How would you even measure dermis temperature?
