Get a small, lab-grade porcelain mortar and pestle, such as the Cole-Parmer AO-63100-61 Mortar and Pestle Set, Porcelain, 50 mL, from Amazon (~ $18). I bought a larger stainless steel one, but I don’t like it as much, as the powder from crushing tends to cling to the sides and is harder to remove. Also get a small milligram scale (Digital Milligram Scale 50g x 0.001g, Mini Precision Scale) for ~$13.
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Important to note that CCR5 is a critical but not sole driver of muscle aging via SASP. The authors reinforce this: The CCL3/4/5-CCR5 axis amplifies SASP (inflammation, niche disruption), but senescence involves a network (e.g., NF-κB, AP-1 TFs like JUNB/ATF3; other SASPs like CXCL8/IL6/TGFB1). Heterogeneity across cells and multiple pathways (e.g., ECM remodeling, growth factors) means no single driver dominates.
Also, no specific data exists yet on gut impacts in non-HIV contexts like sarcopenia or aging. (Virtually every ingested drug may impact the gut microbiome as we are learning that it has an “elephant memory.”)
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Maraviroc (300mg twice daily) plus pravastatin (10mg once daily) for 6 to 12 weeks form the basis of Dr Bruce Patterson’s Long COVID (PASC) protocol, which is theorized to interrupt the monocytic-endothelial-platelet axis and restore immune dysregulation in that condition.
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Patterson, B. K., Yogendra, R., Guevara-Coto, J., Mora-Rodriguez, R. A., Osgood, E., Bream, J., Parikh, P., Kreimer, M., Jeffers, D., Rutland, C., Kaplan, G., & Zgoda, M. (2023). Case series: Maraviroc and pravastatin as a therapeutic option to treat long COVID/Post-acute sequelae of COVID (PASC). Frontiers in medicine, 10, 1122529. Frontiers | Case series: Maraviroc and pravastatin as a therapeutic option to treat long COVID/Post-acute sequelae of COVID (PASC)
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Patterson, B. K., Guevara-Coto, J., Mora, J., Francisco, E. B., Yogendra, R., Mora-Rodríguez, R. A., Beaty, C., Lemaster, G., Kaplan DO, G., Katz, A., & Bellanti, J. A. (2024). Long COVID diagnostic with differentiation from chronic lyme disease using machine learning and cytokine hubs. Scientific reports, 14(1), 19743. Long COVID diagnostic with differentiation from chronic lyme disease using machine learning and cytokine hubs | Scientific Reports
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Patterson, B. K., Francisco, E. B., Yogendra, R., Long, E., Pise, A., Rodrigues, H., Hall, E., Herrera, M., Parikh, P., Guevara-Coto, J., Triche, T. J., Scott, P., Hekmati, S., Maglinte, D., Chang, X., Mora-Rodríguez, R. A., & Mora, J. (2022). Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection. Frontiers in immunology, 12, 746021. Frontiers | Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection
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Patterson, B. K., Guevara-Coto, J., Yogendra, R., Francisco, E. B., Long, E., Pise, A., Rodrigues, H., Parikh, P., Mora, J., & Mora-Rodríguez, R. A. (2021). Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning. Frontiers in immunology, 12, 700782. Frontiers | Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning
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https://www.healthrising.org/blog/2023/03/21/patterson-long-covid-chronic-fatigue-lyme-poll/
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How are you taking this and what dose
are you doing. It looks like you have to inject it
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It sounds like you would just take a break from the two pills so you won’t be doing them at the same time. Maybe do a month loading of this then do it maybe one a month and take that week off from the rapamycin? Any thoughts are good.
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Our dose schedule for FOX04-DRI
Yes it is a subQ injection. I’m a bit of a peptide junky and with our current morning and night cycles we are doing 8 - 9 injections per day.
As an update, I started Maraviroc 4 days ago and unless I’m just being in a good mood or something I seem to have some significant improvement on pain and aches plus very little inflammation, and my tinnitus is almost gone it is like a 2-3 out of ten, and used to have it a solid 6-7 out of 10. If this continues, I have to say this is my favorite health intervention so far, and I’ve tried over 100 supplements and over 20 FDA approved drugs. My only caveat is I just so happen to decide increasing HGH from my normal 3IU per day to 5IU per day the same day I started Maraviroc, so while I suspect all the positive benefits are because of Maraviroc, maybe some % of it can be attributed to the increase in HGH also.
Anyway, I felt so good that I thought I needed to update you guys. It would be interesting if any of you have had similar experience on it. I know there is few taking it and It would be nice if you give us an update.
Oh, almost forgot, I used to have an afternoon fatigue daily and that is also totally gone in last 3-4 days.
BTW, I’m cutting 150mg in four parts and taking 1/4th daily with the dinner.
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Seriously? What were you thinking? Totally voids any data on the Maraviroc.
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“Benefits over 3 months of treatment
Metric / Improvement
Muscle Mass, +28%”
Can anyone determine just were this statistic came from? Seems unbelievable.
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From the original paper at the top of the page: Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia | Nature Communications
Maraviroc (MVC) Treatment Efficacy
The following improvements were observed in 18-month-old mice treated with MVC (10 mg/kg) for 3 months compared to the control group:
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Muscle Mass (+28%)
- Data Point: The treatment resulted in a “28.01% increase of TA [Tibialis Anterior] /body weight”.
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Fiber Diameter (+15%)
- Data Point: Histological analysis revealed that “muscle fiber size was increased (15.50%)”.
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Grip Strength (+16%)
- Data Point: Muscle function was enhanced, evidenced by a “notable increase in the grip strength (15.79%)”.
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Endurance (+20%)
- Data Point: The treatment led to a “tapered grip strength reduction (Δgrip) (19.75%),” indicating improved resistance to fatigue.
- Note: While treadmill running distance increased by 50.00%, the +20% figure in your query corresponds to the improvement in grip endurance (Δgrip).
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As @KarlT mentions, that basically invalidates your N=1 trial. I would expect these results you mention just from the HGH increase. Really there needs to be a independent introduction of the Maraviroc alone over a specific period of time.
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I will see my personal physician on Feb. 2nd.
All my blood work results are back and looks fantastic.
I am going to show him the research and request to go on Maraviroc as I slow down my HGH dose to 2.5 iu daily.
He supports trying what research shows improves one’s health. So far, TRT, Rapa, HGH and Jardiance (SGLT2) - all have reflected a great blood panel.
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Yeah, true but I wasn’t expecting any results especially this fast that’s why I upped the dose without paying much attention that I had already started Maraviroc (about same time). So, this was a big surprise to me. The thing though is I doubt HGH would have such an effect since I have been doing 3IUdaily for few months already. I mean it could be maybe a little help (5iu vs 3iu) but doubt to be this big of a difference. So, I still think it is Maraviroc.
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Even if this would translate to 50% of these results (in humans) that would be HUGE. I’ve lost at most 5-7% of my grip strength and endurance at 60 vs 30 and to have a single medication to reverse it all and then some that would be nothing short of a miracle drug in my opinion. Many thanks for finding and posting such studies/info. One of those days I’m sure we will hit the longevity jackpot and uncover the fountain of youth substance/medicine LOL.
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That’s why I’m hesitant to believe it. “If it’s too goo to be true….”
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Aren’t you then making the same mistake as @Kelman, changing two variables at the same time?
What dose are you planning?
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Hahaha - I am going down slightly at the end of my thymus rejuvenation protocol - I have been on HGH for a full year. My benefits are pretty stable including IGF- 1 score past 2 tests.
Looking for muscle growth/size with Maraviroc… and continued senescent cell removal which will show up in lower inflammation - using GlycanAge test.
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I think Maraviroc renders senescent cells useless as in “puts them to sleep” as opposed to clearing them out. At least that’s what I read in one of the posted studies. But once they’re inactive and unable to do monkey business within us then probably that’s same effect as removing them.
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You’re taking a quarter pill with dinner every night? What dosing frequency are you using.
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Once I land on a dosing protocol I’m going to start the regimen and report back. My workouts, supplements, macronutrient intake, TRT, etc are all very consistent and have been for years. I will not alter them or introduce any new cofounders into my routine in order to get a clear idea of any perceived efficacy of the drug. I got 60 150mg tablets from India.
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